CLUSTAL 2.1 multiple sequence alignment [Homo ---------------------------------------------MTSIFHFAIIFMLIL [Pan ---------------------------------------------MPSIFHFAIIFMLIL [Macaca ---------------------------------------------MTSIFHFAIIFMLTL [Canis ------------------------------------------MKTNPSIFQFAIIFILIL [Mus ------------------------------------------MTKPNSLIFYCIIVLGLT [Rattus MLLVKNSGERGQVCTPLQKLSLYPSGDALMNSSSLKHVYCHTMTKTQSTIFYCIVVLGLI * : :.*:.: [Homo QIRIQLSEESEFLVDRSKNGLIHVPKDLSQKTTILNISQNYISELWTSDILSLSKLRILI [Pan QIRIQLSEESEFLVDRSKNGLIHVPKDLSQKTTILNISQNYISELWTSDILSLSKLRILI [Macaca QIRIQLSEESEFLVDRSKNSLIHVPKDLSQKTTILNISQNYISELWTSDILSLSKLRILI [Canis EIRIQLSEESDFLVNRSKAGLFHIPKDLSLKTTILDISQNYISELQTSDILSLSKLRILI [Mus LMKIQLSEECELIIKRPNANLTRVPKDLPLQTTTLDLSQNNISELQTSDILSLSKLRVLI [Rattus LIKIQLSEESELIIKRPNANLTRVPKDLPLQTTTLDVSQNNISELQTSDILLLSKLRVFI ::******.::::.*.: .* ::****. :** *::*** **** ***** *****::* [Homo ISHNRIQYLDISVFKFNQELEYLDLSHNKLVKISCHPTVNLKHLDLSFNAFDALPICKEF [Pan ISHNRIQYLDISVFKFNHELEYLDLSHNKLVKISCHPTVNLKHLDLSFNAFDALPICKEF [Macaca ISHNRLQYLDISVFKFNQELEYLDLSHNKLAKISCHPTVNLKHLDLSFNAFDALPICKEF [Canis VSYNRIQYLDISVFKFNQELEYLDLSHNELGRISCHPTVNLKHLDLSFNAFDDLPICKEF [Mus MSYNRLQYLNISVFKFNTELEYLDLSHNELKVILCHPTVSLKHLDLSFNAFDALPICKEF [Rattus MSYNRLQYLNISVFKFNTELEYLDLSHNELRLISCHATADLKHLDLSFNAFDALPICKEF :*:**:***:******* **********:* * **.*..************ ******* [Homo GNMSQLKFLGLSTTHLEKSSVLPIAHLNISKVLLVLGETYGEKEDPEGLQDFNTESLHIV [Pan GNMSQLKFLGLSTTHLEKSSVLPIAHLNISKILLVLGETYGEKEDPEGLQDFNTESLHIV [Macaca GNMSQLKFLGLSTTHLEKSTVLPIAHLNISKVLLVLGEHYGDKEDPEGLQNFNTESLHIV [Canis GNMSQLEFLGLSATQLQKSSMLPIASLHIRKVLLVLGDTYGKKEDPESLQKLNTESLHIV [Mus GNMSQLQFLGLSGSRVQSSSVQLIAHLNISKVLLVLGDAYGEKEDPESLRHVSTETLHIV [Rattus GNLSQLQFLGLSGSQIQNSSVQLIAHLNISKVLLVLGDTYGEKEDPKCLQHISTETLHIV **:***:***** ::::.*:: ** *:* *:*****: **.****: *:...**:**** [Homo FPTNKEFHFILDVSVKTVANLELSNIKCVLEDNKCSYFLSILAKLQTNPKLSNLTLNNIE [Pan FPTNKEFHFILDVSVKTVANLELSNIKCVLEDNKCSYFLSILAKLQTNPKLSSLTLNNIE [Macaca FPTSKEFNFILDVSVRTVANLELSNIKCVLEDNECSYFLNILAKLQTNPKLSSLTLNNIE [Canis FPIRKEFSFTLDVSVSTAVSLELSNIKCVPDGHGWSYFQNVLSKLQKNSRLSSLTLNNIE [Mus FPSKREFRFLLDVSVSTTIGLELSNIKCVLEDQGCSYFLRALSKLGKNLKLSNLTLNNVE [Rattus FPSKREFHFLLDMSVSTAISLELSNIKCVLEDKNCSYFLGTLERLRKTQRLSNLTLNNVD ** :** * **:** *. .********* :.: *** * :* .. :**.*****:: [Homo TTWNSFIRILQLVWHTTVWYFSISNVKLQGQLDFRDFDYSGTSLKALSIHQVVSDVFGFP [Pan TTWNSFIRILQLVWHTTVWYFSISNVKLQGQLDFRDFDYSGTSLKALSIHQVVSDVFSFP [Macaca TTWNSFIRILQLVWHTTVWYFSISNVKLQGQLDFRDFDYSGTSLKALSVHQVVSDVFNFP [Canis TTWNFFIMLLQLVWHTSIEYFSISNVKLQGYPDFRDFDYSDTSLKALSIHQVVSNAFNLP [Mus TTWNSFINILQIVWHTPVKYFSISNVKLQGQLAFRMFNYSDTSLKALSIHQVVTDVFSFP [Rattus TTWNSFINILQLVWHTPVKSFSISNVKLKGHFNFRRFHYSDTSLRALSIHQVVTDVFSFP **** ** :**:****.: ********:* ** *.**.***:***:****::.*.:* [Homo QSYIYEIFSNMNIKNFTVSGTRMVHMLCPSKISPFLHLDFSNNLLTDTVFENCGHLTELE [Pan QSDIYEIFSNMNIKNFTVSGTRMVHMLCPSKISPFLHLDFSNNLLTDTVFENCGHLTELE [Macaca QRDIYEIFSNMNIKNFTVSGTRMIHMVCPSKISPFLHLDFSNNLLTDTVFENCGHLTELE [Canis QSYIYKIFSNMNIQNFTVSGTHMVHMVCPSQISPFLHLDFSNNLLTDIVFKNCRNLIKLE [Mus QSYIYSIFANMNIQNFTMSGTHMVHMLCPSQVSPFLHVDFTDNLLTDMVFKDCRNLVRLK [Rattus QSNIYSIFSNMNIQSFTVSGTRMVHMLCPDQISPFLYLDFTDNLLTDIVFEDCRNLIRLK * **.**:****:.**:***:*:**:**.::****::**::***** **::* :* .*: [Homo TLILQMNQLKELSKIAEMTTQMKSLQQLDISQNSVSYDEKKGDCSWTKSLLSLNMSSNIL [Pan TLILQMNQLKELSKIAEMTTQMKSLQQLDISQNSVSYDEKKGDCSWTKSLLSLNMSSNIL [Macaca TLILQMNQLKELSKIAEMTTRMKSLQQLDISQNSVSYDEKKGDCSWTKSLLSLNMSSNIL [Canis TLSLQMNQLKELASIAQMTNEMKSLQQLDISQNSLRYDENEGNCSWTRSLLSLNMSSNIL [Mus TLSLQKNQLKNLENIILTSAKMTSLQKLDISQNSLRYSDGGIPCAWTQSLLVLNLSSNML [Rattus TLSLQKNQLKTLENIILMSMEMTSLQKLDISQNSLRYSDAGSPCSWTQSLLVLNLSSNML ** ** **** * .* : .*.***:*******: *.: *:**:*** **:***:* [Homo TDTIFRCLPPRIKVLDLHSNKIKSIPKQVVKLEALQELNVAFNSLTDLPGCGSFSSLSVL [Pan TDTIFRCLPPRIKVLDLHSNKIKSVPKQVVKLEALQELNVAFNSLTDLPGCGSFSSLSVL [Macaca TDTIFKCLPPRIKVLDLHSNKIKSIPKQVIKLEALQELNVAFNSLTDLPGCGSFSSLSVL [Canis TDSVFRCLPPKVKVLDLHDNRIRSIPKPIMKLEDLQELNVASNSLAHFPDCGTFNRLSVL [Mus TGSVFRCLPPKVKVLDLHNNRIMSIPKDVTHLQALQELNVASNSLTDLPGCGAFSSLSVL [Rattus TDSVFRCLPPKVKVLDLHNNRIVSISKDVTHLQALQELNVASNFLTDLPGCGAFSSLSVL *.::*:****::******.*:* *:.* : :*: ******* * *:.:*.**:*. **** [Homo IIDHNSVSHPSADFFQSCQKMRSIKAGDNPFQCTCELGEFVKNIDQVSSEVLEGWPDSYK [Pan IIDHNSVSHPSADFFQSCQKMRSIKAGDNPFQCTCELREFVKNIDQVSSEVLEGWPDSYK [Macaca IIDHNSVSHPSADFFQSCQKMRSIKAGNNPFQCTCELREFVKNIEQVSSEVVEGWPDSYK [Canis IIDSNSISNPSADFLQSCHNIRSISAGNNPFQCTCELREFVQSLGQVASKVVEGWPDSYK [Mus VIDHNSVSHPSEDFFQSCQNIRSLTAGNNPFQCTCELRDFVKNIGWVAREVVEGWPDSYR [Rattus VIDHNSVSHPSSDFFQSCQNIRSITAGNNPFRCTCELREFVKNIGQASREVVEGWPDSYR :** **:*:** **:***:::**:.**:***:***** :**:.: .: :*:*******: [Homo CDYPESYRGTLLKDFHMSELSCNITLLIVTIVATMLVLAVTVTSLCSYLDLPWYLRMVCQ [Pan CDYPESYRGSPLKDFHMSELSCNITLLIVTIVATMLVLAVTVTSLCIYLDLPWYLRMVCQ [Macaca CDYPESYRGTPLKDFHMSELSCNITLLIVTIGATMLVLAVTVTFLCIYLDLPWYLRMVCQ [Canis CDSPENYKGTLLKDFHVSPLSCNTTLLLVTIGVAVLVFTVTVTALCIYFDLPWYLRMVFQ [Mus CDYPESSRGTALRDFHMSPLSCDTVLLTVTIGATMLVLAVTGAFLCLYFDLPWYVRMLCQ [Rattus CDYPDSIKGTPLQDFHMSPLSCDTILLTVTIGATLLLLAAIGASLCLYFDLPWYLRMLWQ ** *:. :*: *:***:* ***: ** *** .::*:::. : ** *:*****:**: * [Homo WTQTRRRARNIPLEELQRNLQFHAFISYSGHDSFWVKNELLPNLEKEGMQICLHERNFVP [Pan WTQTRRRARNIPLEELQRNLQFHAFISYSGHDSFWVKNELLPNLEKEGMQICLHERNFVP [Macaca WTQTRRRARNVPLEELQRNLQFHAFISYSGHDSFWVKNELLPNLEKEGMQICLHERNFVP [Canis WTQTRRRARNTPLENLQRTIQFHAFISYSGHDSAWVKSELLPNLEKEELRICLHERNFIP [Mus WTQTRHRARHIPLEELQRNLQFHAFVSYSGHDSAWVKNELLPNLEKDDIQICLHERNFVP [Rattus WTQTRHRARNIPLEELQRNLQFHAFVSYSGHDSAWVKNELLPNLEKDDIRVCLHERNFVP *****:***: ***:***.:*****:******* ***.********: :::*******:* [Homo GKSIVENIITCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHNLFHEGSNSLILILLEPIP [Pan GKSIVENIITCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHNLFHEGSNNLILILLEPIP [Macaca GKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHNLFHEGSNNLILILLEPIP [Canis GKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHNLFHEGSNNLILILLEPIP [Mus GKSIVENIINFIEKSYKSIFVLSPHFIQSEWCHYELYFAHHNLFHEGSDNLILILLAPIP [Rattus GKSIVENIIHFIEKSYKSIFVLSPHFIQSEWCHYELYFAHHNLFHEGSDNLILILLEPIP ********* *************:*:*********************:.****** *** [Homo QYSIPSSYHKLKSLMARRTYLEWPKEKSKRGLFWANLRAAINIKLTEQAKK------ [Pan QYSIPSSYHKLKSLMARRTYLEWPKEKSKRGLFWANLKAAINIKLTEQAKK------ [Macaca QYSIPSSYHKLKNLMARRTYLEWPKEKSKHGLFWANLRAAINIKLTEQAKK------ [Canis QYSIPSSYHKLKNLMAQRTYLEWPKEKSKHGLFWANLRASINIKLREQAKK------ [Mus QYSIPTNYHKLKTLMSRRTYLEWPTEKNKHGLFWANLRASINVKLVNQAEGTCYTQQ [Rattus QYSIPTNYHKLKTLMARRTYLEWPTEKSKHGLFWANLRASINVKLVNQAEATCYTQQ *****:.*****.**::*******.**.*:*******:*:**:** :**: