CLUSTAL 2.1 multiple sequence alignment [Mus ---------MLRALWLFWILVAITVLFS-KRCSAQES-LSCDASGVCDGRSRSFTSIPSG [Rattus ---------MLQALWLFWILMAVIGLSR-EGHSAQAS-LSCDAAGVCDGSSRSFTSIPSG [Homo ---------MPHTLWMVWVLGVIISLSK-EESSNQAS-LSCDRNGICKGSSGSLNSIPSG [Pan ---------MPHTLWMVWVLGVIISLSK-EESSNQAS-LSCDRNGICKGSSGSLNSIPSG [Macaca ---------MPHTLWMVWVLGVIISLSK-EESSNQAS-LSCDHNGICKGSSGSLNSIPSV [Canis ---------MSRVLWTLWVLGAVTNLSK-EEAPDQSSSLSCDPTGVCDGRSRSLNSMPSG [Bos ---------MPRALWTAWVW-AVIILST-EGASDQASSLSCDPTGVCDGHSRSLNSIPSG [Gallus MFNQSKQKPTMKLMWQAWLIYTALAAHLPEEQALRQACLSCDATQSCNCSFMGLDFIPPG [Danio ---------MRLVGTMTAIILIMFILAQGLECSQTCK---CDQMYFCNCSSNNLHQVPT- : . ** *. .: :*. [Mus LTAAMKSLDLSFNKITYIGHGDLRACANLQVLMLKSSRINTIEGDAFYSLGSLEHLDLSD [Rattus LTANTKKLDLSFNKITYIGHGDLRACVNLRVLTLESSGINTIEGDAFYSLGSLEHLDLSN [Homo LTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSY [Pan LTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSY [Macaca LTEAVKCLDLSNNRITYISNSDLQRYVNLQALVLTSNGINTIEEDSFSSLGRLEHLDLSY [Canis LTAAVRSLDLSNNEITYIGNSDLRDCVNLKALRLESNGINTIEEESFFSLWSLEHLDLSY [Bos LTAGVKSLDLSNNDITYVGNRDLQRCVNLKTLRLGANEIHTVEEDSFFHLRNLEYLDLSY [Gallus LTGKITVLNLAHNRIKLIRTHDLQKAVNLRTLLLQSNQISSIDEDSFGSQGKLELLDLSN [Danio VPSDVLGLDLSFNQIESINMTDLSSYNELIILNLHKNKLRHIHRDAFKSQHNLEVLDLSL :. *:*: * * : ** :* * * . : :. ::* ** **** [Mus NHLSSLSSSWFGPLSSLKYLNLMGNPYQTLGVTSLFPNLTNLQTLRIGNVETFSEIRRID [Rattus NHLSSLSSSWFRPLSSLKYLNLMGNPYRTLGETSLFSNLTNLQTLRVGNVDTFSEIRRID [Homo NYLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMDTFTKIQRKD [Pan NYLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMDTFTKIQRKD [Macaca NYLSNLSSSWFKPLSSLKFLNLLGNPYKTLGETSLFSHLTKLRILRVGNMDTFTKIQRKD [Canis NLLSNLSSSWFRPLSSLKFLNLLGNPYKSLGETPLFSQLTNLRILKVGNIYSFTEIQDKD [Bos NRLSNLSSSWFRSLYVLKFLNLLGNLYKTLGETSLFSHLPNLRTLKVGNSNSFTEIHEKD [Gallus NSLAHLSPVWFGPLFSLQHLRIQGNSYSDLGESSPFSSLRNLSSLHLGN-PQFSIIRQGN [Danio NNLNNLSPSWFHKLKSLQQLNLVGNPYSTVGPAPIFSSLVNLRTLHLGS-PSLRELHKNG * * **. ** * * *.: ** * :* :. *. * :* *::*. : :: . [Mus FAGLTSLNELEIKALSLRNYQSQSLKSIRDIHHLTLHLS-----ESAFLLEIFADILSSV [Rattus FAGLTSLNELEIQVLSLGNYESRSLQSIRDIYHLTLHLS-----ESAFLLGIFADILSSV [Homo FAGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMK-----QHILLLEIFVDVTSSV [Pan FAGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMK-----QHILLLEIFVDVTSSV [Macaca FAGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMK-----QHILLLEIFVDLTSSV [Canis FAGLTFLEELEIDASNLQRYEPKSLKSIQSISYLALRMK-----QPVLLVEIFVDLSSSL [Bos FTGLTFLEELEISAQNLQIYVPKSLKSIQNISHLILHLK-----QPILLVDILVDIVSSL [Gallus FEGIVFLNTLRIDGDNLSQYEPGSLKSIRKINHMIISIR-----RIDVFSAVIRDLLHSA [Danio LDVLTHLDEMTFFGSNLRSYENGSLKAARPIGSVSLSLQNLFESDPELVSKVLQDVSHPE : :. *: : : .* * **:: : : : : : .. :: *: . [Mus RYLELRDTNLARFQFSPLPVDEVSSPMKKLAFRGSVLTDESFNELLKLLRYILELSEVEF [Rattus RYLELRDTNLARFQFSELSVDEINSPMKKLAFRNADLTDKSFNELLKLLRYILELMEVEF [Homo ECLELRDTDLDTFHFSELSTGETNSLIKKFTFRNVKITDESLFQVMKLLNQISGLLELEF [Pan ECLELRDTDLDTFRFSELSTGETNSLIKKFTFRNVKITDESLFQVMKLLNQISGLLELEF [Macaca ECLELRDTDLNTFHFSELSTGETNSLIKKFTFRNVKITDESLFQVMKLLSQISGLLELEF [Canis KHLELRDTHLDTFHFSEASINETHTLVKKWTFRNVKVTDRSFTEVVRLLNYVSGVLEVEF [Bos DCFELRDTNLHTFHFSEASISEMSTSVKKLIFRNVQFTDESFVEVVKLFNYVSGILEVEF [Gallus IWLEVREIKLDIENEKLVQNSTLPLTIQKLTFTGASFTDKYISQIAVLLKEIRSLRELEA [Danio TLLIIKDVTMKTNTSTEPFKMVKEGGTKSLTFQNSSTTDQALTSFLEFMDGSP-LSFIGL : ::: : . :. * . **. : .. :: : : [Mus DDCTLNGLGDFNPSESDVVSELGKVETVTIRRLHIPQFYLFYDLSTVYSLLEKVKRITVE [Rattus DHCTLNGVGNFNPSESDVVRELGKVETVTIRSLHIPQFYLFYDLSTVYSLLEKVKRITVE [Homo DDCTLNGVGNFRASDNDRVIDPGKVETLTIRRLHIPRFYLFYDLSTLYSLTERVKRITVE [Pan DDCTLNGVGNFRASDNDRVIDPGKVETLTIRRLHIPRFYLFYDLSTLYSLTERVKRITVE [Macaca DDCTLNGVGDFRGSDNDRVIDPGKVETLTIRRLHIPQFYSFNDLSTLYPLTERVKRITVE [Canis EDCTLYGLGDFDIPDVDKIKNIGQIETLTVRRLHIPHFYSFYDMSSIYSLTEDVKRITVE [Bos DDCTHDGIGDFRALSLDRIRHLGNVETLTIRKLHIPQFFLFHDLSSIYPLTGRVKRVTIE [Gallus IDCVLEGKGAWDMTEIARSKQ-SSIETLSITNMTILDFYLFFDLEGIETQVGKLKRLSIA [Danio EDIQFVGIGEWQK---AKYTHHDSLRTAYLRNIEIEGFFGFSSMIELGFLLKHFHNVSVI . * * : . ..:.* : : * *: * .: : .:.::: [Mus NSKVFLVPCSFSQHLKSLEFLDLSENLMVEEYLKNSACKG--AWPSLQTLVLSQNHLRSM [Rattus NSKVFLVPCSFSQHLKSLEFLDLSENLMVEEYLKNSACEG--GWPSLQSLVLSQNHLRSI [Homo NSKVFLVPCLLSQHLKSLEYLDLSENLMVEEYLKNSACED--AWPSLQTLILRQNHLASL [Pan NSKVFLVPCLLSQHLKSLEYLDLSENLIVEEYLKNSACED--AWPSLQTLILRQNHLASL [Macaca NSKVFLVPCLLSRHLKSLEYLDLSENLMVEEYLKNSACED--AWPSLQTLILRQNHLASL [Canis SSKVFLVPCSLSQHLKSLEYLDLSDNLVVEEYLRNSACQH--AWPLLQTLILRQNRLKSL [Bos NSKVFLVPCLLSQHLKSLEYLDLSENLMSEETLKNSACKD--AWPFLQTLVLRQNRLKSL [Gallus SSKVFMVPCRLARYFSSLLYLDFHDNLLVNNRLGETICED--AWPSLQTLNLSKNSLKSL [Danio NATVFVIPKETTFLLKNLEYMDLSQNLLTDLTIQPTLYTGSGAYQNLNMLNVSQNVLKSL .:.**::* : :..* ::*: :**: : : : .: *: * : :* * *: [Mus QKTGEILLTLKNLTSLDISRNTFHPMPDSCQWPEKMRFLNLSSTGIRVVKTCIPQTLEVL [Rattus RKTAEILLTLKNLTALDISKNSFQPMPDSCQWPGKMRFLNLSSTGIQAVKTCIPQTLEVL [Homo EKTGETLLTLKNLTNIDISKNSFHSMPETCQWPEKMKYLNLSSTRIHSVTGCIPKTLEIL [Pan EKTGETLLTLKNLTNVDISKNSFHSMPETCQWPEKMKYLNLSSTRIHSVTGCIPKTLEIL [Macaca GKIGETLLTLKNLTNLDISKNTFHYMPETCQWPEKMKYLNLSSTRIHSVTGCIPKTLEIL [Canis EKTGETLLTLKNLVNLDISKNNYLSMPETCQWPEKLKCLNLSDTRMQSITRCIPQTLEIL [Bos EKTGELLLTLENLNNLDISKNNFLSMPETCQWPGKMKQLNLSSTRIHSLTQCLPQTLEIL [Gallus KQAARYISNLHKLINLDISENNFGEIPDMCEWPENLKYLNLSSTQIPKLTTCIPSTLEVL [Danio GLMSRLVTNLKKLKYLDLSYNSFVSMPEKCSWPVTLRFLNLSSTKLSTLTPCLPSSLTVL .. : .*.:* :*:* *.: :*: *.** .:: ****.* : :. *:*.:* :* [Mus DVSNNNLDSFSLFLPRLQELYISRNKLKTLPDASLFPVLLVMKIRENAVSTFSKDQLGSF [Rattus DVSNNNLDSFSLFLPRLQELYISRNKLKTLPEASLFPVLQVMKIRENAISTFSKDQLGSF [Homo DVSNNNLNLFSLNLPQLKELYISRNKLMTLPDASLLPMLLVLKISRNAITTFSKEQLDSF [Pan DVSNNNLNLFSLNLPQLKELYISRNKLMTLPDASLLPMLLVLKISRNAITTFSKEQLDSF [Macaca DISNNNLNLFSLNLPQLKELYISRNKLMTLPDASLLPMLLVLKISRNTITTFSKEQLDSF [Canis DVSNNNLESFSLILPQLKELSISRNKLKTLPDASFLPTLQIMRISRNTINAFSKEQLDSF [Bos DVSNNNLDSFSLILPQLKELYISRNKLKTLPDASFLPVLSVMRISRNIINTFSKEQLDSF [Gallus DVSANNLQDFGLQLPFLKELYLTKNHLKTLPEATDIPNLVAMSISRNKLNSFSKEEFESF [Danio DLSENDLKAFKQRFPHLTTLILTGNRLMKLPDGKLFPSLNTLLIQRNALRMFNQSSLRSF *:* *:*. * :* * * :: *:* .**:.. :* * : * .* : *.:..: ** [Mus PKLETLEAGDNHFVCSCELLSFTMETPALAQILVDWPDSYLCDSPPRLHGHRLQDARPSV [Rattus PKLETLEAGDNHFICSCELLSFILERPALVHVLVDWPDSYLCDSPPRLHGQRLQDARPSV [Homo HTLKTLEAGGNNFICSCEFLSFTQEQQALAKVLIDWPANYLCDSPSHVRGQQVQDVRLSV [Pan HTLKTLEAGGNNFICSCEFLSFTQEQQALAKVLIDWPANYLCDSPSHVRGQQVQDVRLSV [Macaca HTLKTLEAGGNNFICSCEFLSFTQEQQALAKVLVDWPANYLCDSPSHVRGQRVQDVRLSV [Canis HRLQTLEAGGNNFLCSCEFLSFTQEQQALAGLLVGWPEDYLCHSPSYVRGQRVGTARLPA [Bos QQLKTLEAGGNNFICSCDFLSFTQGQQALGRVLVDWPDDYRCDSPSHVRGQRVQDARLSL [Gallus KQMELLDASANNFICSCEFLSFIHHEAGIAQVLVGWPESYICDSPLTVRGAQVGSVQLSL [Danio KTLLYLEAGANNFVCSCKFVSFFKKDVEDLITLQDGRQNYVCNTPFTLRGNAIDSVRLSV : *:*. *:*:***.::** * . .* *.:* ::* : .: . [Mus LECHQAALVSGVCCALLLLILLVGALCHHFHGLWYLRMMWAWLQAKRKPKK-APCRDVCY [Rattus LECHQAALVSGVCCALLLLILLLGALCYHFHGLWYLRMMWAWLRAKRKPKK-APCRDLCY [Homo SECHRTALVSGMCCALFLLILLTGVLCHRFHGLWYMKMMWAWLQAKRKPRK-APSRNICY [Pan SECHRTALVSGMCCALFLLILLTGVLCHRFHGLWYMKMMWAWLQAKRKPRK-APSRNICY [Macaca SECHRAALVSGMCCALFLLILLMGVLCHRFHGLWYMKMMWAWLQAKRKPRK-APNRDICY [Canis SECHRTALVAAVCCVLLLLVLLTAGACHHFHGLWYLRMLWAWLQAKRKPRK-APSRDVCY [Bos SECHRAAVVSAACCALFLLLLLTGVLCHRFHGLWYMKMMWAWLQAKRKPRK-APRRDICY [Gallus MECHRSLLVSLICTLVFLFILILVVVGYKYHAVWYMRMTWAWLQAKRKPKR-APTKDICY [Danio FECYMIPAVSVLCFGIITALGLVVLTCHKLHVIWYLQMTKAWIQAKRKPAVGRLPEELRY **: *: * :: : : :: * :**::* **::***** .:: * [Mus DAFVSYSEQDSHWVENLMVQQLENSDPPFKLCLHKRDFVPGKWIIDNIIDSIEKSHKTVF [Rattus DAFVSYSEQDSYWVENLMVQQLENSDPPFKLCLHKRDFVPGKWIIDNIIDSIEKSHKTVF [Homo DAFVSYSERDAYWVENLMVQELENFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTVF [Pan DAFVSYSERDAYWVENLMVQELENFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTVF [Macaca DAFVSYSERDAYWVENLMVQELENFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTVF [Canis DAFVSYSEHDSYWVENLLVQKLEHFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTIF [Bos DAFVSYSERDSYWVENLMVQELEHFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTIF [Gallus DAFVSYSENDSNWVENIMVQQLEQACPPFRLCLHKRDFVPGKWIVDNIIDSIEKSHKTLF [Danio DAFVSYSQHDAEWVEEILVAELEDTQPSFSLCLHKRDFRPGRWIVDNIIDSIEKSYRTLF *******:.*: ***:::* :**. *.* ******** **:**:**********::*:* [Mus VLSENFVRSEWCKYELDFSHFRLFDENNDAAILVLLEPIERKAIPQRFCKLRKIMNTKTY [Rattus VLSENFVRSEWCKYELDFSHFRLFDENNDAAILVLLEPIEKKAIPQRFCKLRKIMNTKTY [Homo VLSENFVKSEWCKYELDFSHFRLFDENNDAAILILLEPIEKKAIPQRFCKLRKIMNTKTY [Pan VLSENFVKSEWCKYELDFSHFRLFDENNDAAILILLEPIEKKAIPQRFCKLRKIMNTKTY [Macaca VLSENFVKSEWCKYELDFSHFRLFDENNDAAILVLLEPIEKKAIPQRFCKLRKIMNTKTY [Canis VLSENFVKSEWCKYELDFSHFRLFDENNDAAILILLEPIEKKAIPQRFCKLRKIMNTKTY [Bos VLSENFVKSEWCKYELDFSHFRLFDENNDAAILILLEPIDKKAIPQRFCKLRKIMNTKTY [Gallus VLSEHFVQSEWCKYELDFSHFRLFDENNDVAILILLEPIQSQAIPKRFCKLRKIMNTKTY [Danio VLSEHFVSSEWCRYELDFSHFRIMDEHNDSAVLVLLEPIKKETIPKRFCKLRKIMNSRTY ****:** ****:*********::**:** *:*:*****. ::**:**********::** [Mus LEWPLDEGQQEVFWVNLRTAIKS--- [Rattus LEWPLDEGQREVFWANLRTAIKS--- [Homo LEWPMDEAQREGFWVNLRAAIKS--- [Pan LEWPMDEAQREGFWVNLRAAIKS--- [Macaca LEWPMDEARQEGFWVNLRAAIKS--- [Canis LEWPTDDAQQEGFWLNLRTAIKS--- [Bos LEWPVDETQQEGFWLNLRAAIRS--- [Gallus LEWPPDEEQQQMFWENLKAALKS--- [Danio LEWPEDEDKRDEFWSNLRAALQRDEC **** *: ::: ** **::*::