The genomic organization and virus structure of SARS-CoV-2
Par Naoum Salamé
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Dernière modification
14/05/2020 10:58
(A) The structure of SARS-CoV-2 consists of a single-stranded positive-sense RNA as the genetic material, which is surrounded by the nucleocapsid protein in the core area and a peripheral envelope consisting of the spike (S) protein, Envelope protein, and Membrane protein. (B) The genomic organization of SARS-CoV-2 is based on a single-stranded positive-sense RNA, which contains a 5ʹ-methylated cap and 3ʹ-polyadenylated tail and is arranged in the following order: the 5ʹ end; open reading frame (ORF) 1a/b; envelope; membrane; nucleoprotein; accessory proteins such as orf 3, 6, 7a, 7b, 8 and 9b; and the 3ʹ end.