CLUSTAL 2.1 multiple sequence alignment [Canis MKRIRSIYIFCSIAISVQGWASKLPEERELTTNCSNMSLRKIPADLTPTTTTLDLSYNLL [Bos MRYIRSIYIFCSIVTSVRSGASELPEERELTTNFSSMSLTKVPEGLTPITTTLDLSYNLL [Homo MRLIRNIYIFCSIVMTAEGDAPELPEERELMTNCSNMSLRKVPADLTPATTTLDLSYNLL [Pan MRLIRNIYIFCSIVMTVEGDAPELPEERELMTNCSNMSLRKVPADLTPATTTLDLSYNLL [Macaca MRLIRNIYIFCSIVMTVEGEAPELPEERELMTNCSNMSLRKVPADLTPATTTLDLSYNLL [Rattus MRLISSIYTLYNIIMSTEAWAPRPTDERELISNYSNMALRKVPPDVTPATTILDLSYNLL *: * .** : .* :... *.. .:**** :* *.*:* *:* .:** ** ******** [Canis SQLQSSDFRSVSKLKVLILCHNRIQELNIKIFEFNRELRYLDLSYNRLKIVTWYSLAGLR [Bos FQLQHSDFRSLSKLKVLILCHNRIQELDIKTFEFNKELSYLDVSNNRLKSVTWFSLAGLR [Homo FQLQSSDFHSVSKLRVLILCHNRIQQLDLKTFEFNKELRYLDLSNNRLKSVTWYLLAGLR [Pan FQLQSSDFHSVSKLRVLILCHNRIQQLDLKTFEFNKELRYLDLSNNRLKSVTWYLLAGLR [Macaca FQLQSSDFHSVSKLKVLILRHNRIQQLNLKTFEFNKELRYLDLSNNRLKSVTWYLLAGLR [Rattus YQFQSSDFHSFSKLRFLILCHNSIQQLDTKIFDLNKELSYLDLSYNRLQSITWSSLVDLR *:* ***:*.***:.*** ** **:*: * *::*:** ***:* ***: :** *..** [Canis HLDLSFNDFDTVPICEETGNMSHLEILGLSGAKIQKSNFQKIAHLHLKTVFLGLRSLSHY [Bos HLDLSFNDFDTLPISVETGNMSHLETLGLSGAKIQKSDFQKIAHLQLNTVLLGLRTLSHY [Homo YLDLSFNDFDTMPICEEAGNMSHLEILGLSGAKIQKSDFQKIAHLHLNTVFLGFRTLPHY [Pan YLDLSFNDFDTMPICEEAGNMSHLEILGLSGAKIQKSDFQKIAHLHLNTVFLGFRTLSHY [Macaca YLDLSFNDFDTMPICEEAGNMSHLEILGLSGAKIQKSDFQKIAHLHLNSVFLGFRTLSHY [Rattus HLDLSFNDFDTLPACEEIGNMRHLETLGLSGAKIQRSDLQKIANLQFSTVFIGLNTLSHY :**********:* . * *** *** *********:*::****:*::.:*::*:.:*.** [Canis EEGSLPILNTTKLHIVLPMNTNFWVLLHDGIKTSKILEMTNIDG-KSQFASYGTQKNLTL [Bos EEGSLPILNTTRLHIVLPVNTNFWVLLHDGIKTSKILEVINIDLQKSQFTSYESQQIPIL [Homo EEGSLPILNTTKLHIVLPMDTNFWVLLRDGIKTSKILEMTNIDG-KSQFVSYEMQRNLSL [Pan EEGSLPILNTTKLHIVLPMDTNFWVLLRDGIKTSKILEMTNIDG-KSQFVSYEMQRNLSL [Macaca EEGSLPILNTTKLHIVLPMDTNFWVLLRDGIKTSKILEMTNIDG-KSQFVSYEMQRNISL [Rattus EEGSLPVLNTTVLHIVLPMAANFWVLLCDGMKTSKVVEMSNIGG-KSQFVSYETPRTLSV ******:**** ******: :****** **:****::*: **. ****.** : : [Canis ENSKTSILLLNKVDLLWDDLLLIFQFVWHTSVECFQIQHLTFGGKVYLDHYSFDYSNTVM [Bos ENAKTSILLLNKVDLSWDDLFLIFQLVWHTSVEYFQIQHVTFGGKVYLDHNSFDYSNTVM [Homo ENAKTSVLLLNKVDLLWDDLFLILQFVWHTSVEHFQIRNVTFGGKAYLDHNSFDYSNTVM [Pan ENAKTSILLLNKVDLLWDDLFLILQFVWHTSVEHFQIRNVTFGGKAYLDHNSFDYSNTVM [Macaca ENAKTSVLLLNKVDLLWDDLFHILQFVWHTSVEHFQIQNVTFGGKAYLDHNSFDYSNTVM [Rattus ENTKASTLIFHKVDLLWDDLLHVFQFVWQTSVECFQIQDLTFGGMASRDHSSFDYSNTVM **:*:* *:::**** ****: ::*:**:**** ***:.:**** . ** ********* [Canis RTIKLEHVQFRIFYIPQERVYLLFTKMDIENLTISDAQMPYMLFPIYPTRFQYLNFANNI [Bos RTIKLEHVHFRIFNIPQESIYLLFTKMDIENLTISDAQMPHMLFPMYPTRFQYLNFANNI [Homo RTIKLEHVHFRVFYIQQDKIYLLLTKMDIENLTISNAQMPHMLFPNYPTKFQYLNFANNI [Pan RTIKLEHVHFRVFYIQQDKIYLLLTKMDIENLTISNAQMPHMLFPNYPTKFQYLNFANNI [Macaca RTIKLEHVHFRVFYIQQDNIYLLLTKMDIENLTISNAQMPHMLFPNYPTKFQYLNFANNI [Rattus KAVILESIHFRIFFIPQNKIYLFFTQMDLENLTISDAQMPHLLFPSHPQSFQHLNFANNI ::: ** ::**:* * *: :**::*:**:******:****::*** :* **:******* [Canis LTDDLFKQPIQLPHLKTLILKGNKLETFSLVSFFANNTSLKHLDLSQNLLQHENGENCFW [Bos LTDDVFKKSIQLPHLKTLILKDNKLETLSLVSHFASNTSLRHLDLSENLLQHENDENCLW [Homo LTDELFKRTIQLPHLKTLILNGNKLETLSLVSCFANNTPLEHLDLSQNLLQHKNDENCSW [Pan LTDELFKRTIQLPHLKTLILNGNKLETLSLVSCFANNTPLEHLDLSQNLLQHKNDENCSW [Macaca LTDELFKRTIQLPHLKTLLLNSNKLETLSLVSCFANNTPLEHLDLSQNLLQHKNDENCSW [Rattus LTDDLFKNPIQMPYLKTLVLRGNQLETLSLVSLFANHTSLLHLDLSQNLLQHGNGEKCMW ***::**..**:*:****:*..*:***:**** **.:*.* *****:***** *.*:* * [Canis PETLITMNLSSNKFADSVFRCLPRNIQILDLNNNKIQTVPKDIIHLKSLQELNLAFNFLT [Bos PETLVTMNLSFNKFADSVFGCLPRNIQILDLNSNKIQTVPKAITHLTSLRELNLAFNFLT [Homo PETVVNMNLSYNKLSDSVFRCLPKSIQILDLNNNQIQTVPKETIHLMALRELNIAFNFLT [Pan PETVVNMNLSYNKLSDSVFRCLPKSIQILDLNNNKIQTVPKETIHLMALRELNIAFNFLT [Macaca PETVVNMNLSYNKLSDSVFRCLPKGIQILDLNNNQIQTVPKETIHLMALRELNIAFNFLT [Rattus PDTLILLNLSSNKFDGSVFRCLPKSIQTLDLNNNKIRAVPKEIIYLKSLRELSIAFNFLT *:*:: :*** **: .*** ***:.** ****.*:*::*** :* :*:**.:****** [Canis DLPGCSHFRKLSILNIEMNLILSPSLDFFQSCQEVKILNAGRNPFRCTCELRDFIQLEEY [Bos DLPGCSHFRRLLVLNVEMNLILSSSLDFFQSCQEVKTLNAGRNPFRCTCELRDFIQLGKY [Homo DLPGCSHFSRLSVLNIEMNFILSPSLDFVQSCQEVKTLNAGRNPFRCTCELKNFIQLETY [Pan DLPGCSHFSRLSILNIEMNFILSPSLDFVQSCQEVKTLNAGRNPFRCTCELKNFIQLETY [Macaca DLPGCSHFSRLSILNVEMNLILSPSLDFVQSCQEVKTLNAGRNPFRCTCELKNFIQLETY [Rattus DLPGCDHFKRLSSLNIEMNLILSPSLDFFQSCQEVKTLNAGRNPFRCICEFRDFIWLEKH *****.** :* **:***:***.****.******* ********** **:::** * : [Canis SEGMMIGWLDSYICEYPLTLKGTLLKDVHLPELSCNTTLLIVTIVVIMLVLGMAVAFCCF [Bos SEGMMVGWSDSYICEYPLNLKGTQLKDVHLPEISCNTGLLIVTIVVVMLVLGMAVAFCCL [Homo SEVMMVGWSDSYTCEYPLNLRGTRLKDVHLHELSCNTALLIVTIVVIMLVLGLAVAFCCL [Pan SEVMMVGWSDSYTCEYPLNLRGTRLKDVHLHELSCNTALLIVTIVVIMLVLGLAVAFCCL [Macaca SEVMMVGWSDSYTCEYPLNLRGTRLKDVHLPELSCNTALLIVTIVVIMLVLGLAVAFCCL [Rattus SKGLMSEWPDSYACEYPLSLKGTPLKDVYLPELACNTTLLIVTIVLVILVLGLVVAFCIL *: :* * *** *****.*:** ****:* *::*** *******:::****:.**** : [Canis YFDLPWYLRMLGQWT--LQRIRKTTQEQLKRNVQFHVFIAYSEHDSTWVKHELIPNLEKK [Bos HFDLPWYLRMLHQWTQTWLRVRKTTQEQLKRSVQFHVFISYSEHDSAWVKYELIPSLEKE [Homo HFDLPWYLRMLGQCTQTWHRVRKTTQEQLKRNVRFHAFISYSEHDSLWVKNELIPNLEKE [Pan HFDLPWYLRMLGQCTQTWHRVRKTTQEQLKRNVRFHAFISYSEHDSLWVKNELIPNLEKE [Macaca HFDLPWYFRMLGQCTQTWHRVRKTTQEQLKRNVRFHAFISYSEHDSLWVKNELIPNLEKE [Rattus KFDMLWYLRVLAQCIRTQHRVRKTVREERKRSVQFHAFISYAAHDSVWVKNELIPNLETE **: **:*:* * *:***.:*: **.*:**.**:*: *** *** ****.**.: [Canis EK--LICLHEGNFDPGKSIIENIMNCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHSLFH [Bos DGSVLICLHEGNSDPGKSMTEDTINCIEKSYKSIFVLSPSFVQTEWCHYEPYFAHHNLFH [Homo DGSILICLYESYFDPGKSISENIVSFIEKSYKSIFVLSPNFVQNEWCHYEFYFAHHNLFH [Pan DGSILICLYESYFDPGKSISENIVSFIEKSYKSIFVLSPNFVQNEWCHYEFYFAHHNLFH [Macaca DGSILICLYERYFDPGKSISENIVSFIEKSYKSIFVLSPNFVQNEWCHYEFYFAYHNLFH [Rattus DGSVLLCLPERNFDPDRSIAENIISCTEKSYKSIFVLSPNFVQNGWCHNELYLAHHNPFR : *:** * **.:*: *: :. ************.***. *** * *:*:*. *: [Canis ENSDYIIFILLEPIPLYCIPTKYPKLKALMEKKAYLEWPKDRRICGLFWANLRAAINANL [Bos ESLDYIILILLEPIPLYCIPTRYPELKALMEKKAYLEWPKDRRKCGLFWANLRAALHVNL [Homo ENSDHIILILLEPIPFYCIPTRYHKLKALLEKKAYLEWPKDRRKCGLFWANLRAAINVNV [Pan ENSDHIILILLEPIPFYCIPTRYHKLKALLEKKAYLEWPKDRRKCGLFWANLRAAINVNV [Macaca ENSDHIILILLEPIPFYCIPTRCHKLKTLLEKKAYLEWPKDRRKCGLFWANLRVAINVNI [Rattus DNYDYIIPILLEPIPSYCVPTKFPKLKALLEKKVYLEWPKDRRKHGLFWANLRAAINVNL :. *:** ******* **:**: :**:*:***.********* ********.*::.*: [Canis LETREMYELQTFVGLNEESQGSAISLIRTDCL [Bos LDTRGTCELQTFTELNEGFGGSAISLIRTDCL [Homo LATREMYELQTFTELNEESRGSTISLMRTDCL [Pan SATREMYELQTFTELNEESRGSTISLMRTDCL [Macaca SATREMYELQTFTELNEESRGSTVSLMRTDCL [Rattus SDTRGRCELQTFTKPNADCQGSTISLVRTDSF ** *****. * **::**:***.: