CLUSTAL 2.1 multiple sequence alignment [Mus ---------------------------MVKSLWDSLCN-----MSQDRKPIVGSFHFVCA [Rattus ---------------------------MVKSLWDSLCN-----MSQDREPIVESFHFVCT [Homo -------------------------------------------MTKDKEPIVKSFHFVCL [Pan -------------------------------------------MTKDKEPIVKSFHFVCL [Macaca -------------------------------------------MTKDKEPVVKSFHFVCL [Canis MDHINVGLFLGSLFCSIDLCNLDTYQDALKNSNNPLGNSHFNIMIKDKDSITGSFHFVYI [Bos -------------------------------------------MIKDKESPIRSCHFVYI [Gallus -----------------------------------------------MGSLTSIYVFACV [Danio -------------------------------------------------MKPSSGWWLVS : [Mus LALIVGSMTPFSNELESMVDYSNRNLTHVPKDLPPRTKALSLSQNSISELRMPDISFLSE [Rattus LALIVGSMTQFSDELESVVDYSNKNLTHVPKDLSPSTKSLSLSQNSISDLQMSDISFLSE [Homo MIIIVGTRIQFSDGNEFAVDKSKRGLIHVPKDLPLKTKVLDMSQNYIAELQVSDMSFLSE [Pan MIIIVGTRIHFSDGNEFAVDKSKRGLIHVPKDLPLKTKVLDMSQNYIAELQVSDMSFLSE [Macaca MIIIVGTRIQFSDGSEFAVDKSKRGLTHVPKDLPPKTKVLDMSHNYIAELQVSDISFLSE [Canis VTLIVGTIIQFSDESEFTVDMSNMNLTHVPEDLPPKTKILDMSQNNISELHLSDMSYLSG [Bos VALVFGTIIQFSDESEFVVDMSKTSLIHVPKDLPPKTKVLDLSQNNISELHLSDISFLSG [Gallus FLSILWNNIQPTVENKITANYSGHLLTEVPKNIPVHTHILDLSHNSISEITNFRFTSLSD [Danio VYLTCFHPSLIPAIQRIIVNYSSQNLSSVPDDLKPSTEDLDLSLNHIQSLNCRDFNTTPR . . . .: * * **.:: *. *.:* * * .: :. . [Mus LRVLRLSHNRIRSLDFHVFLFNQDLEYLDVSHNRLQNISCCPMA----SLRHLDLSFNDF [Rattus LRVLRLSHNRIRRLDFGVFLLNRDLEYLDVSHNQLQNISCCPMV----NLKHLDLSFNDF [Homo LTVLRLSHNRIQLLDLSVFKFNQDLEYLDLSHNQLQKISCHPIV----SFRHLDLSFNDF [Pan LKVLRLSHNRIQLLDLSVFKFNQDLEYLDLSHNQLQKISCHPIV----SFRHLDLSFNDF [Macaca LKVLRLSHNKIQLLDLSVFKFNQDLEYLDLSHNQLQKISCHPIM----SFRHLDLSFNDF [Canis LKILRISHNRIWWLDFSIFKFNQDLEYLDLSYNQLRNMSCHLIR----SLKHLDLSFNDF [Bos LRVLRLSHNRIQGLDISIFKFNHDLEYLDLSHNQLQKISCHPITT---TLKHLDLSFNDF [Gallus LQVLNLSHNLITELDFSAFMFNQDLEYLDLSHNNIWTAYCQLLA----RLRHLDLSFNKF [Danio LRFLNLSWNILENIDRDTFTSTPALEMLDLSHNGLQNLSEQPYLLHLGCLELLDLSSNRF * .*.:* * : :* * . ** **:*:* : . :. **** * * [Mus DVLPVCKEFGNLTKLTFLGLSAAKFRQLDLLPVAHLHLSCILLDLVSYHIKGGETESLQI [Rattus EVLPVYKEFGNLRKLSFLGLSAAKFRQLDLLPISHLHLSCVLLDLVNYQIKDGETESLQV [Homo KALPICKEFGNLSQLNFLGLSAMKLQKLDLLPIAHLHLSYILLDLRNYYIKENETESLQI [Pan KALPICKEFGNLSQLNFLGLSAMKLQKLDLLPIAHLHLSYILLDLRNYYIKENETESLQI [Macaca KALPICKQFGNLSQLNFLGLSAMKLQKLDLLPIAHLHLSYILLDLRNYYIKENETESLQI [Canis HVLPICKEFGNLTQLQFLGLSATKLRQLDLLPIAHLHLSYILLDLQGYYAKESEKGSLQI [Bos DALPICKEFGNLTQLNFLGLSATKLQQLDLLPIAHLHLSCILLDLED-YMKENKKESLQI [Gallus TVLPICQEFGIMFHLEYLGLSAMMIRRSDFRYVAHLQLDTVFLTLEDFSLYEP--LSLTA [Danio SAMALGEEFSMLKRLQWLGLSAKSISIQDFTHISNLTLRTLFINADGLLTYEGNSLDDVH .:.: ::*. : :* :***** : *: :::* * ::: . . [Mus PNTTVLHLVFHPNSLFSVQVNMS-VNALGHLQLSNIKLNDENCQRLMTFLSELTRGPTLL [Rattus PNTNVLHLVFHPNSLFSVQVNIS-VNALGCLQLSNIKLNDENCQSLIIFLSELTRGPTLL [Homo LNAKTLHLVFHPTSLFAIQVNIS-VNTLGCLQLTNIKLNDDNCQVFIKFLSELTRGSTLL [Pan LNAKTLHLVFHPTSLFAIQVNIS-VNTLGCLQLTNIKLNDDNCQVFIKFLSELTRGPTLL [Macaca LNAKTLHLVFHPTSLFSIQVNIS-VNTLGCLQLTNIKLNDDNCQVFIKFLLELTRGPTLL [Canis LDTKTLHLVFHPNQLFSVQANML-VNNLGCLQLTNIKLNNDNCQVLIQFLSELTRGPTLL [Bos LNTKKLHLVFHPNSFFSVQVDIS-GNSLACLQLTNIKLNDYNCQVLLKFLSGLTGGPTLL [Gallus LNTRSLHIVFATNQNFNFSLLYDGMSTSEKLKIVNLRYT-LSHKDFPSPSLELQKKIKTT [Danio AEKAVIALSSTNVDIAIANDVFA--------RFKEVEFTKVDGKMEVVQQMRSRALMRTV : : : . . :: ::. . . : [Mus NVTLQHIETTWKCSVKLFQFFWPRPVEYLNIYNLTITERIDR-------------EEFTY [Rattus NLTLQHIETNWKCFVRLLQFLWPRPVEYLNIYNLTITESISR-------------ETFIY [Homo NFTLNHIETTWKCLVRVFQFLWPKPVEYLNIYNLTIIESIRE-------------EDFTY [Pan NFTLNHIETTWKCLVRVFQFLWPKPVEYLNIYNLTIIESIHE-------------EEFTY [Macaca NFTLNHIETTWKCLVRVFQFLWPKPVEYLNIYNLTIIESIHE-------------EDFTY [Canis NFTLQHVKTTWKCLVRIFKFLWPKPVQYLNIYNLTIVESINK-------------EYIHY [Bos NFTLNHVETTWKCLVKVFQFLWPKPIEYLNIYNLTIVESIDE-------------EVFTY [Gallus DLTLDTVDLEWTVILQIFLLVWDSSVEHLTVRNLIFRGPVVELTEYKHVPLLRSLEQLLS [Danio RLEISNVKTTWEFLTSSVNTILSSTIRELSLTDLTLTEMKDG--------------ANQS . :. :. * . . .:. *.: :* : [Mus SETALKSLMIEHVKNQVFLFSKEALYSVFAEMNIKMLSISDTPFIHMVCPPSPSSFTFLN [Rattus VETVLKSLKIEHVTNQVFLFVKDALYSVFAEMNIRMLTLSDTPFIHMVCPEFPSTFAFLN [Homo SKTTLKALTIEHITNQVFLFSQTALYTVFSEMNIMMLTISDTPFIHMLCPHAPSTFKFLN [Pan SKTTLKALKIEHITNKVFLFSQTALYTVFSEMNIMMLTISDTPFIHMLCPHAPSTFKFLN [Macaca SKTTLKALKIEHITNQVFIFSQTALYTVFSEMNIMMLTISDTPFIHMLCPHAPSTFKFLN [Canis PKTALKALTIEHVKNEVFLFSQTALYTIFSEMNIMMLTISDTPFIHMLCPPPSNTFKFLN [Bos YKTTLKALKIEHITNKVFIFSQTALYTVFSEMNILMLTISDTRFIHMLCPQEPSTFKFLN [Gallus LGSSMKALTLERVRNKLYYFNQEILYRQFSEMNIDSLTIHDACMPHMLCPKKRSSFQYIN [Danio STHILESFSTKRASVTTFIFDQKMLYDFFINTPARKVSLTESPIIFMTCPGTISKIQELD :::: :: : * : ** * : ::: :: : .* ** ..: :: [Mus FTQNVFTDSVFQG-----CSTLKRLQTLILQRNGLKNFFKVALMTKNMSSLETLDVSLNS [Rattus FTQNVFTDSIFQG-----CSTLKRLETLILQRNGLKNLFKVALMTKTMSSLETLDVSLNS [Homo FTQNVFTDSIFEK-----CSTLVKLETLILQKNGLKDLFKVGLMTKDMPSLEILDVSWNS [Pan FTQNVFTDSIFEK-----CSTLVKLETLILQKNGLKDLFKVGLMTKDMPSLEILDVSWNS [Macaca FTQNVFTDSIFEK-----CSTLVKLETLILQKNGLKDLFKVGLMTKDMPSLEILDVSWNS [Canis FTQNVFTDSVFQS-----CSHLVRLETLILRKNKLKDLYKVGLMTKHMTSLEILDVSVNS [Bos FTQNSFTDSVFQN-----CDTLARLETLILQKNELKDLFKTSLMTKDMLSLETLDVSWNS [Gallus FSRNALTDELFQN-----CDTLANLKILILHRNKFESLSKVSFMTSRMKSLRYLDMSSNL [Danio LSDCALTEKIFSVNPETECGTLVNLTRLVLRGNNLKHLSPLTSRINLMDSLQYIDLSQNT :: :*:.:*. *. * .* *:*: * :: : . * **. :*:* * [Mus LNSHAYDRTCAWAESILVLNLSSNMLTGSVFRCLPPKVKVLDLHNNRIMSIPKDVTHLQA [Rattus LNSHVYDRTCAWAESIRVLNLSSNVLSDSVFRCLPPKVKVLDLHNNRIVSIPKDVTHLQA [Homo LESGRHKENCTWVESIVVLNLSSNMLTDSVFRCLPPRIKVLDLHSNKIKSVPKQVVKLEA [Pan LESGRHKENCTWVESIVVLNLSSNMLTDSVFRCLPPRIKVLDLHSNKIKSVPKQVIKLKA [Macaca LESGRHRENCTWVESIVVLNLSSNILTDSVFRCLPPRIKVLDLHNNKIKSIPKQVVKLEA [Canis LEYDRYDGNCTWVGSIVVLNLSSNILTDSVFRCLPPKVKVLDLHDNRIRSIPKPIMKLED [Bos LEYDRSNGNCSWVGSIVVLNLSSNALTDSVFRCLPPRIKVLDLHNNRIRSIPKDVTGLET [Gallus LRNSRAEGRCQWADSLAELDLSSNQLTEAVFECLPANINKVDLQNNQIANVPKGITELHS [Danio LTYSENQGRCFWPPRVLHVDLSRNGFDEVVFKCLPDSVQVLNLRHNRVSTVPADIHTFDT * * * : ::** * : **.*** :: ::*: *:: .:* : :. [Mus LQELNVASNSLTDLPGCGAFSSLSVLVIDHNSVSHPSEDFFQSCQNIRSLTAGNNPFQCT [Rattus LQELNVASNFLTDLPGCGAFSSLSVLVIDHNSVSHPSSDFFQSCQNIRSITAGNNPFRCT [Homo LQELNVAFNSLTDLPGCGSFSSLSVLIIDHNSVSHPSADFFQSCQKMRSIKAGDNPFQCT [Pan LQELNVAFNSLTDLPGCGSFSSLSVLIIDHNSVSHPSADFFQSCQKMRSIKAGDNPFQCT [Macaca LQELNVAFNSLTDLPGCGSFSSLSVLIIDHNSVSHPSADFFQSCQKMRSIKAGNNPFQCT [Canis LQELNVASNSLAHFPDCGTFNRLSVLIIDSNSISNPSADFLQSCHNIRSMSAGNNPFQCT [Bos LQELNLASNSLAHLPGCGIFSSLSILIIEHNSISNPSADFFQSCQKIRSLKAGNNPFQCS [Gallus LQELNLASNRLADLPGCRAFTGLEILNIERNLILTPSADFFETCPSVKELQAGQNPFKCS [Danio LQVIDLTFNRLLDLPTCRSFPSLQKLLIRSNSIHSPVPGSLKTCQHLQDLDLSHNPFICT ** :::: * * .:* * * *. * * * : * . :::* ::.: ..*** *: [Mus CELRDFVKNIGWVAREVVEG----WPDSYRCDYPESSKGTALRDFHMSPLSCDTVLLTVT [Rattus CELREFVKNIGQASREVVEG----WPDSYRCDYPDSIKGTPLQDFHMSPLSCDTILLTVT [Homo CELREFVKNIDQVSSEVLEG----WPDSYKCDYPESYRGSPLKDFHMSELSCNITLLIVT [Pan CELRQFVKSIDQVSSEVLEG----WPDSYKCDYPESYRGTPLKDFHMSELSCNITLLIIT [Macaca CELREFIKNIEQVSSEVVEG----WPDSYKCDYPESYRGTPLKDFHMSELSCNITLLIVT [Canis CELREFVQSLGQVASKVVEG----WPDSYKCDSPENYKGTLLKDFHVSPLSCNTTLLLVT [Bos CELRDFIQSVGQVSSDVVEG----WPESYKCDYPESYKGTPLKDFQVSELSCNTALLIIT [Gallus CELQDFLR-LERQSGGKLSG----WPEAYVCKYPEDLSGTQLEDFHLTELACNTTLLLVT [Danio CALRDFASLINAQGIKTFKSTLKHWPDGYRCSYPESWSNSTLEDFYLPEISCNAWILAIT * *::* : . ... **:.* *. *:. .: *.** :. ::*: :* :* [Mus IGATMLVLAVTGAFLCLYFDLPWYVRMLCQWTQTRHRARHIPL-EELQRNLQFHAFVSYS [Rattus IGATLLLLAAIGASLCLYFDLPWYLRMLWQWTQTRHRARNIPL-EELQRNLQFHAFVSYS [Homo IGATMLVLAVTVTSLCIYLDLPWYLRMVCQWTQTRRRARNIPL-EELQRNLQFHAFISYS [Pan IGATMLVLAVTVTSLCIYLDLPWYLRMVCQWTQTRRRARNIPL-EELQRNLQFHAFISYS [Macaca IGATMLVLAVTVTFLCIYLDLPWYLRMVCQWTQTRRRARNVPL-EELQRNLQFHAFISYS [Canis IGVAVLVFTVTVTALCIYFDLPWYLRMVFQWTQTRRRARNTPL-EELQRTIQFHAFISYS [Bos IVVPGLVLAVAVTVLCIYLDLPWYLRMVCQWTQTRRRARNVPL-EELQRTLQFHAFISYS [Gallus ALLLTLVLVAVVAFPCIYLDVPWYVRMLWQWTQTKRRAWHDCP-EERETALQFHAFISYS [Danio ILIPTISLIVAVSLLCNRLDIPWYVRMMWKWTRAKHYSITSQLKEEDVERLHFHAFVSYS : : . : * :*:***:**: :**:::: : ** ::****:*** [Mus EHDSAWVKNELLPNLEKDD--IRVCLHERNFVPGKSIVENIINFIEKSYKAIFVLSPHFI [Rattus EHDSAWVKNELLPNLEKDD--IRVCLHERNFVPGKSIVENIIHFIEKSYKSIFVLSPHFI [Homo EHDSAWVKSELVPYLEKED--IQICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFV [Pan EHDSAWVKTELVPYLEKED--IQICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFV [Macaca EHDSAWVKNELVPYLEKEG--MQICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFV [Canis EHDSAWVKNELVPCLEKEE--LRICLHERNFIPGKSIVENIINCIEKSYKSIFVLSPNFV [Bos EHDSAWVKNELIPNLEKED--IRICLHERNFVAGKSIVENIINCIEKSYKSIFVLSPNFV [Gallus ERDSLWVKNELIPNLEKGEGCIQLCQHERNFIPGKSIVENIINCIEKSYKSIFVLSPNFV [Danio QKNAGWVKSQFLPKLEGDCG-LRMCHHERDFIPGKTVVQNILRCIEQSRRCVFVLSSHFV :::: ***.:::* ** :::* ***:*:.**::*:**:. **:* :.:****.:*: [Mus QSEWCHYELYFAHHNLFHEGSDNLILILLEPILQNNIPSRYHKLRALMAQRTYLEWPTEK [Rattus QSEWCHYELYFAHHNLFHEGSDNLILILLEPIQQNNIPSRYHKLRALMAQRTYLEWPIEK [Homo QSEWCHYELYFAHHNLFHEGSNNLILILLEPIPQNSIPNKYHKLKALMTQRTYLQWPKEK [Pan QSEWCHYELYFAHHNLFHEGSNNLILILLEPIPQNSIPNKYHKLKALMMQRTYLQWPKEK [Macaca QSEWCHYELYFAHHNLFHEGSNNLILILLEPIPQNSIPNKYHKLRALMTQRTYLQWPKEK [Canis QSEWCHYELYFAHHNLFHEGSNNLILILLEPIPQNCIPSKYHKLRALMTQRTYLEWPKEK [Bos QSEWCHYELYFAHHNLFHEGSDNLILILLDPIPQYSIPSSYHKLRALMAQRTYLEWPKEK [Gallus QSEWCHYELYFAHHRLFSENSNSLILILLEPIPSYVIPARYHKLKALMAKRTYLEWPKER [Danio QSEWCHYELYFANHQKLTRGMDSILLILLEPLPLYLIPSKYYQLKTMMSRRTYLEWPQEG ************:*. : .. :.::****:*: ** *::*:::* :****:** * [Mus GKRGLFWANLRASFIMKLALVNED-DVKT-------------- [Rattus GKRGLFWANLRASFIMKLALVNEN-DVKT-------------- [Homo SKRGLFWANIRAAFNMKLTLVTENNDVKS-------------- [Pan SKRGLFWANIRAAFNMKLTLVTENNDVKS-------------- [Macaca SKRGLFWANIRATFNVKLTLVTENNDVKS-------------- [Canis SKHGLFWANIRAAFNMKLTLIAENNNAEAS------------- [Bos SKHGLFWANLRASINIKLMEKAAEIH----------------- [Gallus SKHALFWANLRAVVNIKLPTSFETDEEQSDVTSTSSITQCLIK [Danio AKQKLFWANLRAALQAELPNTPDREEE---------------- .*: *****:** . :* .