CLUSTAL 2.1 multiple sequence alignment Mus MVLRRRTLHPLSLLVQAAVLAETLALGTLPAFLPCELKPHGLVDCNWLFLKSVPRFSAAA [Rattus MVLCSRTLHPLSLLVQAAVLAEALALGTLPAFLPCELKPHGLVDCNWLFLKSVPHFSAAE [Homo MGFCRSALHPLSLLVQAIMLAMTLALGTLPAFLPCELQPHGLVNCNWLFLKSVPHFSMAA [Macaca MGFCCSALHPLSLLVQAMVLATTLALGTLPAFLPCELQPHGLVNCNWLFLKSVPHFSAAA [Sus MG-PRCTLHPLSLLVQVTALAATLAQGRLPAFLPCELQPHGLVNCNWLFLKSVPHFSAAA [Danio ---MFGPMVSLILLLNQFQLFAASHPQFYPCESHSTKDGHINVDCQHRRLSKVPRFTSP- .: .* **:: * : *. . . * *:*: *..**:*: . Mus SCSNITRLSLISNRIHHLHNSDFVHLSNLRQLNLKWNCPPTGLSPLHFS-CHMTIEPRTF [Rattus PRSNITSLSLIANRIHHLHNLDFVHLPNVRQLNLKWNCPPPGLSPLHFS-CRMTIEPKTF [Homo PRGNVTSLSLSSNRIHHLHDSDFAHLPSLRHLNLKWNCPPVGLSPMHFP-CHMTIEPSTF [Macaca PRGNVTSLSLSSNRIHHLHDSDFARLPSLRRLNLKWNCPPVGLSPMHFP-CHMTIEPSTF [Sus PRANVTSLSLLSNRIHHLHDSDFVHLSSLRTLNLKWNCPPAGLSPMHFP-CHMTIEPNTF [Danio ---SVISLNLNNNHIHRIKGDAFSGLPNLKYLSLMWNCISDRLKEARWPLCSVNIDPDAF .: *.* *:**:::. * *..:: *.* *** . *. ::. * :.*:* :* Mus LAMRTLEELNLSYNGITTVPRLPSSLVNLSLSHTNILVLDANSLAGLYSLRVLFMDGNCY [Rattus LAMRMLEELNLSYNGITTVPRLPSSLTNLSLSHTNILVLDASSLAGLHSLRVLFMDGNCY [Homo LAVPTLEELNLSYNNIMTVPALPKSLISLSLSHTNILMLDSASLAGLHALRFLFMDGNCY [Macaca LAVPTLEELNLSYNSITTVPALPKSLISLSLSHTNILVLDSDSLASLHSLRFLFMDGNCY [Sus LAVPTLEELNLSYNSITTVPALPDSLVSLSLSRTNILVLDPTHLTGLHALRYLYMDGNCY [Danio VGLKNLTSLQLAGNSLKMIPPLPKQLEVLGLEFNNIFNIVKP--LGTPQLKQLLLSKNCF :.: * .*:*: *.: :* **..* *.*. .**: : . *: * :. **: Mus YKNPCTGAVKVTPGALLGLSNLTHLSLKYNNLTKVPRQLPPSLEYLLVSYNLIVKLGPED [Rattus YKNPCNGAVNVTPDAFLGLSNLTHLSLKYNNLTEVPRQLPPSLEYLLLSYNLIVKLGPED [Homo YKNPCRQALEVAPGALLGLGNLTHLSLKYNNLTVVPRNLPSSLEYLLLSYNRIVKLAPED [Macaca YKNPCRQELEVAPGALLGLGNLTHLSLKYNNLTVVPRNLPSSLEYLLLSYNRIIKLAPED [Sus YKNPCQGALEVVPGALLGLGNLTHLSLKYNNLTEVPRSLPPSLETLLLSYNHIVTLTPED [Danio YANPCHQPYFINSSVFQDLPELLNLTLSYNNLTAIPSYLPGSLESLDLRENTIDHINKES * *** : ...: .* :* :*:*.***** :* ** *** * : * * : *. Mus LANLTSLRVLDVGGNCRRCDHAPNPCIECGQ-KSLHLHPETFH-HLSHLEGLVLKDSSLH [Rattus LANLTSLRVLDVGGNCRRCDHAPDLCTECRQ-KSLDLHPQTFH-HLSHLEGLVLKDSSLH [Homo LANLTALRVLDVGGNCRRCDHAPNPCMECPR-HFPQLHPDTFS-HLSRLEGLVLKDSSLS [Macaca LANLTALRVLDVGGNCRRCDHAPNPCMECPR-HFPQLHPDTFS-HLSRLEGLVLKDSSLS [Sus LANLTALRVLDVGGNCRRCDHARNPCRECPK-DHPKLHSDTFS-HLSRLEGLVLKDSSLY [Danio FANLRNLRHLNLGWNCQRCDHASDPCFPCPNNQSLDLHQDAFLDQRDSLVSLHLQGNSLR :*** ** *::* **:***** : * * . . .** ::* : . * .* *:..** Mus TLNSSWFQGLVNLSVLDLSENFLYESINHTNAFQNLTRLRKLNLSFNYRKKVSFARLHLA [Rattus SLNSKWFQGLVNLSVLDLSENFLYESINKTSAFQNLTRLRKLDLSFNYCKKVSFARLHLA [Homo WLNASWFRGLGNLQVLDLSENFLYKCITKTKAFQGLTQLRKLNLSFNYQKRVSFAHLSLA [Macaca WLNASWFRGLGNLRVLDLSENFLYKCITKTKAFQGLTQLRQLNLSFNYHKRVSFAHLSLA [Sus NLDARWFRGLDRLQVLDLSENFLYDCITKTTAFQGLARLRKLNLSFNYHKKVSFAHLHLA [Danio TLPRHLFINLHKLQELDLSSNFLAFTIQNGTFYEELQNVVILNLLYNYEPLKTFPELNLS * * .* .* ****.*** * : . :: * .: *:* :** :*..* *: Mus SSFKNLVSLQELNMNGIFFRSLNKYTLRWLADLPKLHTLHLQMNFINQAQLSIFGTFRAL [Rattus SSFKSLVSLQELNMNGIFFRLLNKNTLRWLAGLPKLHTLHLQMNFINQAQLSVFSTFRAL [Homo PSFGSLVALKELDMHGIFFRSLDETTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFPGL [Macaca PSFGSLVALKELDMHGIFFRSLDETTLRPLAHLPVLQTLRLQMNFISQAQLGIFRAFPGL [Sus PSFGHLRSLKELDMHGIFFRSLSETTLQPLVQLPMLQTLRLQMNFINQAQLSIFGAFPGL [Danio PYIEKMASLRELYLSGFFFKKLSNRSIAPLVKLPRLEVLDLRMNFICDISIDGLSQLRTL . : : :*:** : *:**: *.: :: *. ** *..* *:**** : .:. : : * Mus RFVDLSDNRISGPSTLSEATPEEADDA------EQEELLSADPHPAPLSTPASK------ [Rattus RFVDLSNNRISGPPTLSRVAPEKADEA------EKGVPWPASLTPALPSTPVSK------ [Homo RYVDLSDNRISGASELTATM-GEADGG------EKVWLQPGDLAPAPVDTPSSE------ [Macaca RYVDLSDNRISGASELTATM-QEVVGG------EKVWLQPGDLAPAPVDTPSSE------ [Sus LYVDLSDNRISGAARPVAIT-REVDGR------ERVWLPSRNLAPRPLDTLRSE------ [Danio RRVDLSQNMLAFSSCFSTCTSEAEHQIPERYGNEQFNLQMQELPILNAETQGSKPDYCSF ****:* :: .. *: . .* *: Mus -----NFMDRCKNFKFTMDLSRNNLVTIKPEMFVNLSRLQCLSLSHNSIAQAVNGSQFLP [Rattus -----NFMVRCKNLRFTMDLSRNNLVTIKPEMFVNLSHLQCLSLSHNCIAQAVNGSQFLP [Homo -----DFRPNCSTLNFTLDLSRNNLVTVQPEMFAQLSHLQCLRLSHNCISQAVNGSQFLP [Macaca -----DFRPNCSTLNFTLDLSRNNLVTVRPEMFAQLSHLQCLRLSHNCISQAVNGSQFLP [Sus -----DFMPNCKAFSFTLDLSRNNLVTIQSEMFARLSRLECLRLSHNSISQAVNGSQFVP [Danio YFSMWHFKRQICSKSLYFDLSQNNIPWLNASTFRGMDRVACVDLSYNYISQTLNGHQFSH .* . : :***:**: :... * :.:: *: **:* *:*::** ** Mus LTNLQVLDLSHNKLDLYHWKSFSELP-QLQALDLSYNSQPFSMKGIGHNFSFVAHLSMLH [Rattus LTNLKVLDLSYNKLDLYHSKSFSELP-QLQALDLSYNSQPFSMQGIGHNFSFLANLSRLQ [Homo LTGLQVLDLSHNKLDLYHEHSFTELP-RLEALDLSYNSQPFGMQGVGHNFSFVAHLRTLR [Macaca LTSLQVLDLSHNKLDLYHEHSFTELP-RLEALDLSYNSQPFGMQGVGHNFSFVAHLRTLR [Sus LTSLRVLDLSHNKLDLYHGRSFTELP-RLEALDLSYNSQPFTMQGVGHNLSFVAQLPALR [Danio LSKLSYLNMAYNRIDLYSDKAFQEVSGTLKALDLSNNEFHFIMKGMGHQFTFLTHMSSLI *: * *::::*::*** ::* *:. *:***** *. * *:*:**:::*:::: * Mus SLSLAHNDIHTRVSSHLNSNSVRFLDFSGNGMGRMWDEG-GLYLHFFQGLSGLLKLDLSQ [Rattus NLSLAHNDIHSRVSSRLYSTSVEYLDFSGNGVGRMWDEE-DLYLYFFQDLRSLIHLDLSQ [Homo HLSLAHNNIHSQVSQQLCSTSLRALDFSGNALGHMWAEG-DLYLHFFQGLSGLIWLDLSQ [Macaca HLSLAHNNIHSQVSQQLCSTSLRALDFSGNALGRMWAEG-DLYLHFFQGLSGLIWLDLSQ [Sus YLSLAHNDIHSRVSQQLCSASLCALDFSGNDLSRMWAEG-DLYLRFFQGLRSLVWLDLSQ [Danio ILSLANNHIGLRISNILTSASLKYLIFSGNRLDILWDSWRNQYINLFQGLTNLTHLDISE ****:*.* ::*. * * *: * **** :. :* . . *: :**.* .* **:*: Mus NNLHILRPQNLDNLPKSLKLLSLRDNYLSFFNWTSLSFLPNLEVLDLAGNQLKALTNGTL [Rattus NKLHILRPQNLNYLPKSLTKLSFRDNHLSFFNWSSLAFLPNLRDLDLAGNLLKALTNGTL [Homo NRLHTLLPQTLRNLPKSLQVLRLRDNYLAFFKWWSLHFLPKLEVLDLAGNQLKALTNGSL [Macaca NRLHTLLPHTLDKLPKSLQVLHLRDNYLAFFKWGNLIHLPKLKVLDLAGNQLKALTNGSL [Sus NHLHTLLPRALDNLPKSLKHLHLRDNNLAFFNWSSLTLLPKLETLDLAGNQLKALSNGSL [Danio NQLKSLSPEVIVNLPLSLQVLRVDFNMLTYFPWANISVLQKLCYLNLSSNMLSYLPN--I *.*: * *. : ** ** * . * *::* * .: * :* *:*:.* *. *.* : Mus PNGTLLQKLDVSSNSIVSVVPAFFALAVELKEVNLSHNILKTVDRSWFGP---------- [Rattus PNGTLLQKLDVSSNSIVFVVPAFFALAVELKEVNLSHNILKTVDRSWFGP---------- [Homo PAGTRLRRLDVSCNSISFVAPGFFSKAKELRELNLSANALKTVDHSWFGP---------- [Macaca PAGTRLRRLDVSCNSISFVDPGFFSKAKELRELNLSANALKTVDPSWFGP---------- [Sus PSGTQLRRLDLSGNSIGFVNPGFFALAKQLEELNLSANALKTVEPSWFGS---------- [Danio NFELRLTGLDLSHNRLVAIPKVFLSQAANLKNLNLNNNQLKILDVQALPLPFHKGCTFIP * **:* * : : *:: * :*.::**. * ** :: . : Mus ----IVMNLTVLDVRSNPLHCACGAA-FVDLLLEVQTKVPGLANGVKCGSPGQLQGRSIF [Rattus ----IVMNLTVLDVSSNPLHCACGAP-FVDLLLEVQTKVPGLANGVKCGSPRQLQGRSIF [Homo ----LASALQILDVSANPLHCACGAA-FMDFLLEVQAAVPGLPSRVKCGSPGQLQGLSIF [Macaca ----LASALQILDVSANPLHCACGAA-FIDFLLEVQAAVPGLPSRVKCGSPGQLQGLSIF [Sus ----MVGNLKVLDVSANPLHCACGAT-FVGFLLEVQAAVPGLPSRVKCGSPGQLQGHSIF [Danio GGQHKNRSSCKLVLHANPFTCSCVISGFAKFLRETDLDVPHLTTQVHCGFPESLAGVNVL * : :**: *:* . * :* *.: ** *.. *:** * .* * .:: Mus AQDLRLCLDEVLSWDCFGLSLLAVAVGMVVPILHHLCGWDVWYCFHLCLAWLPLLARSR- [Rattus AQDLRLCLDDVLSRDCFGLSLLAVAVGTVLPLLQHLCGWDVWYCFHLCLAWLPLLTRGR- [Homo AQDLRLCLDEALSWDCFALSLLAVALGLGVPMLHHLCGWDLWYCFHLCLAWLPWRGRQSG [Macaca AQDLRLCLDEALSWDCFTLSLLSVALGLGVPMLHHLCGWDLWYCFHLCLAWLPWRGRQSG [Sus AQDLRLCLDETLSWNCFGISLLAMALGLVVPMLHHLCGWDLWYCFHLCLAWLPHRGQR-- [Danio SVDLRSCQEIFGGVAFLCTSLLTLAA-TCVPLLKHLYGWDLWYLIQILWTGHRGHTPAN- : *** * : . : ***::* :*:*:** ***:** ::: : Mus RSAQALPYDAFVVFDKAQSAVADWVYNELRVRLEERRGRRALRLCLEDRDWLPGQTLFEN [Rattus RSAQALPYDAFVVFDKAQSAVADWVYNELRVRLEERRGRRALRLCLEDRDWLPGQTLFEN [Homo RDEDALPYDAFVVFDKTQSAVADWVYNELRGQLEECRGRWALRLCLEERDWLPGKTLFEN [Macaca QGEDALPYDAFVVFDKTQSAVADWVYNELRGQLEERRGRWALRLCLEERDWLPGKTLFEN [Sus RGADALFYDAFVVFDKAQSAVADWVYNELRVQLEERRGRRALRLCLEERDWLPGKTLFEN [Danio GNPTDTQYDAFVVFDTSNKAVRDWIYKEMLVRLEN-RGRWRFQLCLEERDWIPGVSCIEN . ********.::.** **:*:*: :**: *** ::****:***:** : :** Mus LWASIYGSRKTLFVLAHT---DRVSGLLRTSFLLAQQRLLEDRKDVVVLVILRPDAHRSR [Rattus LWASIYGSRKTLFVLAHT---DKVSGLLRTSFLLAQQRLLEDRKDVVVLVILRPDAHRSR [Homo LWASVYGSRKTLFVLAHT---DRVSGLLRASFLLAQQRLLEDRKDVVVLVILSPDGRRSR [Macaca LWASVYGSRKTLFVLAHT---DRVSGLLRASFLLAQQRLLEDRKDVVVLVILSPDGRRSR [Sus LWASVYSSRKTLFVLAHT---DRVSGLLRASFLLAQQRLLEDRKDVVVLVILRPDAYRSR [Danio LHKSVYSSRKTVFVLTSPGGYSDASGIVRQAFLLVQQRLLDEKVDVAVLVLLDFLFPKFK * *:*.****:***: . . .**::* :***.*****::: **.***:* : : Mus YVRLRQRLCRQSVLFWPQQPNGQGGFWAQLSTALTRDNRHFYNQNFCRGPTAE- [Rattus YVRLRQRLCRQSVLFWPHQPNGQGSFWAQLSTALTRDNHHFYNRNFCRGPTAE- [Homo YVRLRQRLCRQSVLLWPHQPSGQRSFWAQLGMALTRDNHHFYNRNFCQGPTAE- [Macaca YVRLRQRLCRQSVLLWPHQPSGQRSFWAQLGMALTRDNHHFYNRNFCQGPTAE- [Sus YVRLRQRLCRQSVLLWPHQPRGQGSFWAQLGTALTRDNRHFYNRNFCRGPTTAE [Danio YLQMRKRLCKKSVLSWPRNPRVQPLFWNDLRVALVSDNVRAYNKNVTESFF--- *:::*:***::*** **::* * ** :* **. ** : **:*. ..