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Mutations ACE2 - Uniprot

Par Naoum Salamé Dernière modification 05/03/2024 09:44

UNIPROT - ACE2 - Mutagenesis

Mutagenesisi 24 – 26 QAK → KAE: Slightly inhibits interaction with SARS-CoV spike glycoprotein.
Mutagenesisi 31 K → D: Abolishes interaction with SARS-CoV spike glycoprotein.
Mutagenesisi 37 E → A: No effect on interaction with SARS-CoV spike glycoprotein.
Mutagenesisi 38 D → A: No effect on interaction with SARS-CoV spike glycoprotein.
Mutagenesisi 41 Y → A: Strongly inhibits interaction with SARS-CoV spike glycoprotein.
Mutagenesisi 68 K → D: Slightly inhibits interaction with SARS-CoV spike glycoprotein.
Mutagenesisi 82 – 84 MYP → NFS: Inhibits interaction with SARS-CoV spike glycoprotein.
Mutagenesisi 110 E → P: No effect on interaction with SARS-CoV spike glycoprotein.
Mutagenesisi 135 – 136 PD → SM: No effect on interaction with SARS-CoV spike glycoprotein.
Mutagenesisi 160 E → R: No effect on interaction with SARS-CoV spike glycoprotein.
Mutagenesisi 169 R → Q: About 95% loss of angiotensin I cleavage.
Mutagenesisi 192 R → D: No effect on interaction with SARS-CoV spike glycoprotein.
Mutagenesisi 219 R → D: No effect on interaction with SARS-CoV spike glycoprotein.
Mutagenesisi 239 H → Q: No effect on interaction with SARS-CoV spike glycoprotein.
Mutagenesisi 271 W → Q: About 95% loss of angiotensin I cleavage.
Mutagenesisi 273 R → Q: Complete loss of enzyme activity. Does not affect amino acid transport activity of SLC6A19.
Mutagenesisi 309 K → D: No effect on interaction with SARS-CoV spike glycoprotein.
Mutagenesisi 312 E → A: No effect on interaction with SARS-CoV spike glycoprotein.
Mutagenesisi 324 T → A: No effect on interaction with SARS-CoV spike glycoprotein.
Mutagenesisi 338 – 340 NVQ → DDR: No effect on interaction with SARS-CoV spike glycoprotein.
Mutagenesisi 345 H → A: Complete loss of enzyme activity.
Mutagenesisi 350 D → A: No effect on interaction with SARS-CoV spike glycoprotein.
Mutagenesisi 353 K → H, A or D: Abolishes interaction with SARS-CoV spike glycoprotein.
Mutagenesisi 355 D → A: Strongly inhibits interaction with SARS-CoV spike glycoprotein.
Mutagenesisi 357 R → A: Strongly inhibits interaction with SARS-CoV spike glycoprotein.
Mutagenesisi 359 L → K or A: No effect on interaction with SARS-CoV spike glycoprotein.
Mutagenesisi 383 M → A: Slightly inhibits interaction with SARS-CoV spike glycoprotein.
Mutagenesisi 389 P → A: Slightly inhibits interaction with SARS-CoV spike glycoprotein.
Mutagenesisi 393 R → A: Slightly inhibits interaction with SARS-CoV spike glycoprotein.
Mutagenesisi 425 – 427 SPD → PSN: Slightly inhibits interaction with SARS-CoV spike glycoprotein.
Mutagenesisi 465 – 467 KGE → QDK: No effect on interaction with SARS-CoV spike glycoprotein.
Mutagenesisi 481 K → Q: About 80% loss of angiotensin I cleavage.
Mutagenesisi 505 H → A: Complete loss of enzyme activity.
Mutagenesisi 514 R → Q: About 50% loss of angiotensin I cleavage but two-fold greater activity with angiotensin II.
Mutagenesisi 559 R → S: Slightly inhibits interaction with SARS-CoV spike glycoprotein.
Mutagenesisi 603 F → T: No effect on interaction with SARS-CoV spike glycoprotein.