Aller au contenu. | Aller à la navigation

Outils personnels

Plateforme - ACCES
Navigation
Vous êtes ici : Accueil / Thématiques / Génétique moléculaire et évolution / Logiciels / Anagène / Archives / Mucoviscidose-Coding sequence of the full-length transcript (Dp427m)

Mucoviscidose-Coding sequence of the full-length transcript (Dp427m)

Par Naoum Salamé — Dernière modification 23/11/2024 23:15

Coding sequence of the full-length transcript (Dp427m)

 

Exon # 1 Exon # 2
ATG CTT TGG TGG GAA GAA GTA GAG GAC TGT TAT GAA AGA GAA GAT GTT CAA AAG AAA ACA TTC ACA AAA TGG GTA AAT GCA CAA TTT TCT

Met

Leu

Trp

Trp

Glu

Glu

Val

Glu

Asp

Cys

Tyr

Glu

Arg

Glu

Asp

Val

Gln

Lys

Lys

Thr

Phe

Thr

Lys

Trp

Val

Asn

Ala

Gln

Phe

Ser

1

2

3

4

5

6

7

8

9

10

11

12

13

14

15

16

17

18

19

20

21

22

23

24

25

26

27

28

29

30
  Exon # 3
AAG TTT GGG AAG CAG CAT ATT GAG AAC CTC TTC AGT GAC CTA CAG GAT GGG AGG CGC CTC CTA GAC CTC CTC GAA GGC CTG ACA GGG CAA

Lys

Phe

Gly

Lys

Gln

His

Ile

Glu

Asn

Leu

Phe

Ser

Asp

Leu

Gln

Asp

Gly

Arg

Arg

Leu

Leu

Asp

Leu

Leu

Glu

Gly

Leu

Thr

Gly

Gln

31

32

33

34

35

36

37

38

39

40

41

42

43

44

45

46

47

48

49

50

51

52

53

54

55

56

57

58

59

60
Exon # 3 Exon # 4 Exon # 5
AAA CTG CCA AAA GAA AAA GGA TCC ACA AGA GTT CAT GCC CTG AAC AAT GTC AAC AAG GCA CTG CGG GTT TTG CAG AAC AAT AAT GTT GAT

Lys

Leu

Pro

Lys

Glu

Lys

Gly

Ser

Thr

Arg

Val

His

Ala

Leu

Asn

Asn

Val

Asn

Lys

Ala

Leu

Arg

Val

Leu

Gln

Asn

Asn

Asn

Val

Asp

61

62

63

64

65

66

67

68

69

70

71

72

73

74

75

76

77

78

79

80

81

82

83

84

85

86

87

88

89

90
Exon # 5  
TTA GTG AAT ATT GGA AGT ACT GAC ATC GTA GAT GGA AAT CAT AAA CTG ACT CTT GGT TTG ATT TGG AAT ATA ATC CTC CAC TGG CAG GTC

Leu

Val

Asn

Ile

Gly

Ser

Thr

Asp

Ile

Val

Asp

Gly

Asn

His

Lys

Leu

Thr

Leu

Gly

Leu

Ile

Trp

Asn

Ile

Ile

Leu

His

Trp

Gln

Val

91

92

93

94

95

96

97

98

99

100

101

102

103

104

105

106

107

108

109

110

111

112

113

114

115

116

117

118

119

120
Exon # 6
AAA AAT GTA ATG AAA AAT ATC ATG GCT GGA TTG CAA CAA ACC AAC AGT GAA AAG ATT CTC CTG AGC TGG GTC CGA CAA TCA ACT CGT AAT

Lys

Asn

Val

Met

Lys

Asn

Ile

Met

Ala

Gly

Leu

Gln

Gln

Thr

Asn

Ser

Glu

Lys

Ile

Leu

Leu

Ser

Trp

Val

Arg

Gln

Ser

Thr

Arg

Asn

121

122

123

124

125

126

127

128

129

130

131

132

133

134

135

136

137

138

139

140

141

142

143

144

145

146

147

148

149

150
Exon # 6 Exon # 7
TAT CCA CAG GTT AAT GTA ATC AAC TTC ACC ACC AGC TGG TCT GAT GGC CTG GCT TTG AAT GCT CTC ATC CAT AGT CAT AGG CCA GAC CTA

Tyr

Pro

Gln

Val

Asn

Val

Ile

Asn

Phe

Thr

Thr

Ser

Trp

Ser

Asp

Gly

Leu

Ala

Leu

Asn

Ala

Leu

Ile

His

Ser

His

Arg

Pro

Asp

Leu

151

152

153

154

155

156

157

158

159

160

161

162

163

164

165

166

167

168

169

170

171

172

173

174

175

176

177

178

179

180
Exon # 7
TTT GAC TGG AAT AGT GTG GTT TGC CAG CAG TCA GCC ACA CAA CGA CTG GAA CAT GCA TTC AAC ATC GCC AGA TAT CAA TTA GGC ATA GAG

Phe

Asp

Trp

Asn

Ser

Val

Val

Cys

Gln

Gln

Ser

Ala

Thr

Gln

Arg

Leu

Glu

His

Ala

Phe

Asn

Ile

Ala

Arg

Tyr

Gln

Leu

Gly

Ile

Glu

181

182

183

184

185

186

187

188

189

190

191

192

193

194

195

196

197

198

199

200

201

202

203

204

205

206

207

208

209

210
Exon # 7 Exon # 8
AAA CTA CTC GAT CCT GAA GAT GTT GAT ACC ACC TAT CCA GAT AAG AAG TCC ATC TTA ATG TAC ATC ACA TCA CTC TTC CAA GTT TTG CCT

Lys

Leu

Leu

Asp

Pro

Glu

Asp

Val

Asp

Thr

Thr

Tyr

Pro

Asp

Lys

Lys

Ser

Ile

Leu

Met

Tyr

Ile

Thr

Ser

Leu

Phe

Gln

Val

Leu

Pro

211

212

213

214

215

216

217

218

219

220

221

222

223

224

225

226

227

228

229

230

231

232

233

234

235

236

237

238

239

240
Exon # 8
CAA CAA GTG AGC ATT GAA GCC ATC CAG GAA GTG GAA ATG TTG CCA AGG CCA CCT AAA GTG ACT AAA GAA GAA CAT TTT CAG TTA CAT CAT

Gln

Gln

Val

Ser

Ile

Glu

Ala

Ile

Gln

Glu

Val

Glu

Met

Leu

Pro

Arg

Pro

Pro

Lys

Val

Thr

Lys

Glu

Glu

His

Phe

Gln

Leu

His

His

241

242

243

244

245

246

247

248

249

250

251

252

253

254

255

256

257

258

259

260

261

262

263

264

265

266

267

268

269

270
Exon # 8 Exon # 9
CAA ATG CAC TAT TCT CAA CAG ATC ACG GTC AGT CTA GCA CAG GGA TAT GAG AGA ACT TCT TCC CCT AAG CCT CGA TTC AAG AGC TAT GCC

Gln

Met

His

Tyr

Ser

Gln

Gln

Ile

Thr

Val

Ser

Leu

Ala

Gln

Gly

Tyr

Glu

Arg

Thr

Ser

Ser

Pro

Lys

Pro

Arg

Phe

Lys

Ser

Tyr

Ala

271

272

273

274

275

276

277

278

279

280

281

282

283

284

285

286

287

288

289

290

291

292

293

294

295

296

297

298

299

300
Exon # 9 Exon # 10
TAC ACA CAG GCT GCT TAT GTC ACC ACC TCT GAC CCT ACA CGG AGC CCA TTT CCT TCA CAG CAT TTG GAA GCT CCT GAA GAC AAG TCA TTT

Tyr

Thr

Gln

Ala

Ala

Tyr

Val

Thr

Thr

Ser

Asp

Pro

Thr

Arg

Ser

Pro

Phe

Pro

Ser

Gln

His

Leu

Glu

Ala

Pro

Glu

Asp

Lys

Ser

Phe

301

302

303

304

305

306

307

308

309

310

311

312

313

314

315

316

317

318

319

320

321

322

323

324

325

326

327

328

329

330
Exon # 10
GGC AGT TCA TTG ATG GAG AGT GAA GTA AAC CTG GAC CGT TAT CAA ACA GCT TTA GAA GAA GTA TTA TCG TGG CTT CTT TCT GCT GAG GAC

Gly

Ser

Ser

Leu

Met

Glu

Ser

Glu

Val

Asn

Leu

Asp

Arg

Tyr

Gln

Thr

Ala

Leu

Glu

Glu

Val

Leu

Ser

Trp

Leu

Leu

Ser

Ala

Glu

Asp

331

332

333

334

335

336

337

338

339

340

341

342

343

344

345

346

347

348

349

350

351

352

353

354

355

356

357

358

359

360
Exon # 10 Exon # 11
ACA TTG CAA GCA CAA GGA GAG ATT TCT AAT GAT GTG GAA GTG GTG AAA GAC CAG TTT CAT ACT CAT GAG GGG TAC ATG ATG GAT TTG ACA

Thr

Leu

Gln

Ala

Gln

Gly

Glu

Ile

Ser

Asn

Asp

Val

Glu

Val

Val

Lys

Asp

Gln

Phe

His

Thr

His

Glu

Gly

Tyr

Met

Met

Asp

Leu

Thr

361

362

363

364

365

366

367

368

369

370

371

372

373

374

375

376

377

378

379

380

381

382

383

384

385

386

387

388

389

390
Exon # 11
GCC CAT CAG GGC CGG GTT GGT AAT ATT CTA CAA TTG GGA AGT AAG CTG ATT GGA ACA GGA AAA TTA TCA GAA GAT GAA GAA ACT GAA GTA

Ala

His

Gln

Gly

Arg

Val

Gly

Asn

Ile

Leu

Gln

Leu

Gly

Ser

Lys

Leu

Ile

Gly

Thr

Gly

Lys

Leu

Ser

Glu

Asp

Glu

Glu

Thr

Glu

Val

391

392

393

394

395

396

397

398

399

400

401

402

403

404

405

406

407

408

409

410

411

412

413

414

415

416

417

418

419

420
Exon # 11 Exon # 12
CAA GAG CAG ATG AAT CTC CTA AAT TCA AGA TGG GAA TGC CTC AGG GTA GCT AGC ATG GAA AAA CAA AGC AAT TTA CAT AGA GTT TTA ATG

Gln

Glu

Gln

Met

Asn

Leu

Leu

Asn

Ser

Arg

Trp

Glu

Cys

Leu

Arg

Val

Ala

Ser

Met

Glu

Lys

Gln

Ser

Asn

Leu

His

Arg

Val

Leu

Met

421

422

423

424

425

426

427

428

429

430

431

432

433

434

435

436

437

438

439

440

441

442

443

444

445

446

447

448

449

450
Exon # 12
GAT CTC CAG AAT CAG AAA CTG AAA GAG TTG AAT GAC TGG CTA ACA AAA ACA GAA GAA AGA ACA AGG AAA ATG GAG GAA GAG CCT CTT GGA

Asp

Leu

Gln

Asn

Gln

Lys

Leu

Lys

Glu

Leu

Asn

Asp

Trp

Leu

Thr

Lys

Thr

Glu

Glu

Arg

Thr

Arg

Lys

Met

Glu

Glu

Glu

Pro

Leu

Gly

451

452

453

454

455

456

457

458

459

460

461

462

463

464

465

466

467

468

469

470

471

472

473

474

475

476

477

478

479

480
Exon # 12 Exon # 13
CCT GAT CTT GAA GAC CTA AAA CGC CAA GTA CAA CAA CAT AAG GTG CTT CAA GAA GAT CTA GAA CAA GAA CAA GTC AGG GTC AAT TCT CTC

Pro

Asp

Leu

Glu

Asp

Leu

Lys

Arg

Gln

Val

Gln

Gln

His

Lys

Val

Leu

Gln

Glu

Asp

Leu

Glu

Gln

Glu

Gln

Val

Arg

Val

Asn

Ser

Leu

481

482

483

484

485

486

487

488

489

490

491

492

493

494

495

496

497

498

499

500

501

502

503

504

505

506

507

508

509

510
Exon # 13 Exon # 14
ACT CAC ATG GTG GTG GTA GTT GAT GAA TCT AGT GGA GAT CAC GCA ACT GCT GCT TTG GAA GAA CAA CTT AAG GTA TTG GGA GAT CGA TGG

Thr

His

Met

Val

Val

Val

Val

Asp

Glu

Ser

Ser

Gly

Asp

His

Ala

Thr

Ala

Ala

Leu

Glu

Glu

Gln

Leu

Lys

Val

Leu

Gly

Asp

Arg

Trp

511

512

513

514

515

516

517

518

519

520

521

522

523

524

525

526

527

528

529

530

531

532

533

534

535

536

537

538

539

540
Exon # 14 Exon # 15
GCA AAC ATC TGT AGA TGG ACA GAA GAC CGC TGG GTT CTT TTA CAA GAC ATC CTT CTC AAA TGG CAA CGT CTT ACT GAA GAA CAG TGC CTT

Ala

Asn

Ile

Cys

Arg

Trp

Thr

Glu

Asp

Arg

Trp

Val

Leu

Leu

Gln

Asp

Ile

Leu

Leu

Lys

Trp

Gln

Arg

Leu

Thr

Glu

Glu

Gln

Cys

Leu

541

542

543

544

545

546

547

548

549

550

551

552

553

554

555

556

557

558

559

560

561

562

563

564

565

566

567

568

569

570
Exon # 15
TTT AGT GCA TGG CTT TCA GAA AAA GAA GAT GCA GTG AAC AAG ATT CAC ACA ACT GGC TTT AAA GAT CAA AAT GAA ATG TTA TCA AGT CTT

Phe

Ser

Ala

Trp

Leu

Ser

Glu

Lys

Glu

Asp

Ala

Val

Asn

Lys

Ile

His

Thr

Thr

Gly

Phe

Lys

Asp

Gln

Asn

Glu

Met

Leu

Ser

Ser

Leu

571

572

573

574

575

576

577

578

579

580

581

582

583

584

585

586

587

588

589

590

591

592

593

594

595

596

597

598

599

600
Exon # 15 Exon # 16
CAA AAA CTG GCC GTT TTA AAA GCG GAT CTA GAA AAG AAA AAG CAA TCC ATG GGC AAA CTG TAT TCA CTC AAA CAA GAT CTT CTT TCA ACA

Gln

Lys

Leu

Ala

Val

Leu

Lys

Ala

Asp

Leu

Glu

Lys

Lys

Lys

Gln

Ser

Met

Gly

Lys

Leu

Tyr

Ser

Leu

Lys

Gln

Asp

Leu

Leu

Ser

Thr

601

602

603

604

605

606

607

608

609

610

611

612

613

614

615

616

617

618

619

620

621

622

623

624

625

626

627

628

629

630
Exon # 16
CTG AAG AAT AAG TCA GTG ACC CAG AAG ACG GAA GCA TGG CTG GAT AAC TTT GCC CGG TGT TGG GAT AAT TTA GTC CAA AAA CTT GAA AAG

Leu

Lys

Asn

Lys

Ser

Val

Thr

Gln

Lys

Thr

Glu

Ala

Trp

Leu

Asp

Asn

Phe

Ala

Arg

Cys

Trp

Asp

Asn

Leu

Val

Gln

Lys

Leu

Glu

Lys

631

632

633

634

635

636

637

638

639

640

641

642

643

644

645

646

647

648

649

650

651

652

653

654

655

656

657

658

659

660
Exon # 16 Exon # 17
AGT ACA GCA CAG ATT TCA CAG GCT GTC ACC ACC ACT CAG CCA TCA CTA ACA CAG ACA ACT GTA ATG GAA ACA GTA ACT ACG GTG ACC ACA

Ser

Thr

Ala

Gln

Ile

Ser

Gln

Ala

Val

Thr

Thr

Thr

Gln

Pro

Ser

Leu

Thr

Gln

Thr

Thr

Val

Met

Glu

Thr

Val

Thr

Thr

Val

Thr

Thr

661

662

663

664

665

666

667

668

669

670

671

672

673

674

675

676

677

678

679

680

681

682

683

684

685

686

687

688

689

690
Exon # 17
AGG GAA CAG ATC CTG GTA AAG CAT GCT CAA GAG GAA CTT CCA CCA CCA CCT CCC CAA AAG AAG AGG CAG ATT ACT GTG GAT TCT GAA ATT

Arg

Glu

Gln

Ile

Leu

Val

Lys

His

Ala

Gln

Glu

Glu

Leu

Pro

Pro

Pro

Pro

Pro

Gln

Lys

Lys

Arg

Gln

Ile

Thr

Val

Asp

Ser

Glu

Ile

691

692

693

694

695

696

697

698

699

700

701

702

703

704

705

706

707

708

709

710

711

712

713

714

715

716

717

718

719

720
Exon # 17 Exon # 18
AGG AAA AGG TTG GAT GTT GAT ATA ACT GAA CTT CAC AGC TGG ATT ACT CGC TCA GAA GCT GTG TTG CAG AGT CCT GAA TTT GCA ATC TTT

Arg

Lys

Arg

Leu

Asp

Val

Asp

Ile

Thr

Glu

Leu

His

Ser

Trp

Ile

Thr

Arg

Ser

Glu

Ala

Val

Leu

Gln

Ser

Pro

Glu

Phe

Ala

Ile

Phe

721

722

723

724

725

726

727

728

729

730

731

732

733

734

735

736

737

738

739

740

741

742

743

744

745

746

747

748

749

750
Exon # 18 Exon # 19
CGG AAG GAA GGC AAC TTC TCA GAC TTA AAA GAA AAA GTC AAT GCC ATA GAG CGA GAA AAA GCT GAG AAG TTC AGA AAA CTG CAA GAT GCC

Arg

Lys

Glu

Gly

Asn

Phe

Ser

Asp

Leu

Lys

Glu

Lys

Val

Asn

Ala

Ile

Glu

Arg

Glu

Lys

Ala

Glu

Lys

Phe

Arg

Lys

Leu

Gln

Asp

Ala

751

752

753

754

755

756

757

758

759

760

761

762

763

764

765

766

767

768

769

770

771

772

773

774

775

776

777

778

779

780
Exon # 19 Exon # 20
AGC AGA TCA GCT CAG GCC CTG GTG GAA CAG ATG GTG AAT GAG GGT GTT AAT GCA GAT AGC ATC AAA CAA GCC TCA GAA CAA CTG AAC AGC

Ser

Arg

Ser

Ala

Gln

Ala

Leu

Val

Glu

Gln

Met

Val

Asn

Glu

Gly

Val

Asn

Ala

Asp

Ser

Ile

Lys

Gln

Ala

Ser

Glu

Gln

Leu

Asn

Ser

781

782

783

784

785

786

787

788

789

790

791

792

793

794

795

796

797

798

799

800

801

802

803

804

805

806

807

808

809

810
Exon # 20
CGG TGG ATC GAA TTC TGC CAG TTG CTA AGT GAG AGA CTT AAC TGG CTG GAG TAT CAG AAC AAC ATC ATC GCT TTC TAT AAT CAG CTA CAA

Arg

Trp

Ile

Glu

Phe

Cys

Gln

Leu

Leu

Ser

Glu

Arg

Leu

Asn

Trp

Leu

Glu

Tyr

Gln

Asn

Asn

Ile

Ile

Ala

Phe

Tyr

Asn

Gln

Leu

Gln

811

812

813

814

815

816

817

818

819

820

821

822

823

824

825

826

827

828

829

830

831

832

833

834

835

836

837

838

839

840
Exon # 20
CAA TTG GAG CAG ATG ACA ACT ACT GCT GAA AAC TGG TTG AAA ATC CAA CCC ACC ACC CCA TCA GAG CCA ACA GCA ATT AAA AGT CAG TTA

Gln

Leu

Glu

Gln

Met

Thr

Thr

Thr

Ala

Glu

Asn

Trp

Leu

Lys

Ile

Gln

Pro

Thr

Thr

Pro

Ser

Glu

Pro

Thr

Ala

Ile

Lys

Ser

Gln

Leu

841

842

843

844

845

846

847

848

849

850

851

852

853

854

855

856

857

858

859

860

861

862

863

864

865

866

867

868

869

870
Exon # 20 Exon # 21
AAA ATT TGT AAG GAT GAA GTC AAC CGG CTA TCA GAT CTT CAA CCT CAA ATT GAA CGA TTA AAA ATT CAA AGC ATA GCC CTG AAA GAG AAA

Lys

Ile

Cys

Lys

Asp

Glu

Val

Asn

Arg

Leu

Ser

Asp

Leu

Gln

Pro

Gln

Ile

Glu

Arg

Leu

Lys

Ile

Gln

Ser

Ile

Ala

Leu

Lys

Glu

Lys

871

872

873

874

875

876

877

878

879

880

881

882

883

884

885

886

887

888

889

890

891

892

893

894

895

896

897

898

899

900
Exon # 21
GGA CAA GGA CCC ATG TTC CTG GAT GCA GAC TTT GTG GCC TTT ACA AAT CAT TTT AAG CAA GTC TTT TCT GAT GTG CAG GCC AGA GAG AAA

Gly

Gln

Gly

Pro

Met

Phe

Leu

Asp

Ala

Asp

Phe

Val

Ala

Phe

Thr

Asn

His

Phe

Lys

Gln

Val

Phe

Ser

Asp

Val

Gln

Ala

Arg

Glu

Lys

901

902

903

904

905

906

907

908

909

910

911

912

913

914

915

916

917

918

919

920

921

922

923

924

925

926

927

928

929

930
Exon # 21 Exon # 22
GAG CTA CAG ACA ATT TTT GAC ACT TTG CCA CCA ATG CGC TAT CAG GAG ACC ATG AGT GCC ATC AGG ACA TGG GTC CAG CAG TCA GAA ACC

Glu

Leu

Gln

Thr

Ile

Phe

Asp

Thr

Leu

Pro

Pro

Met

Arg

Tyr

Gln

Glu

Thr

Met

Ser

Ala

Ile

Arg

Thr

Trp

Val

Gln

Gln

Ser

Glu

Thr

931

932

933

934

935

936

937

938

939

940

941

942

943

944

945

946

947

948

949

950

951

952

953

954

955

956

957

958

959

960
Exon # 22 Exon # 23
AAA CTC TCC ATA CCT CAA CTT AGT GTC ACC GAC TAT GAA ATC ATG GAG CAG AGA CTC GGG GAA TTG CAG GCT TTA CAA AGT TCT CTG CAA

Lys

Leu

Ser

Ile

Pro

Gln

Leu

Ser

Val

Thr

Asp

Tyr

Glu

Ile

Met

Glu

Gln

Arg

Leu

Gly

Glu

Leu

Gln

Ala

Leu

Gln

Ser

Ser

Leu

Gln

961

962

963

964

965

966

967

968

969

970

971

972

973

974

975

976

977

978

979

980

981

982

983

984

985

986

987

988

989

990
Exon # 23
GAG CAA CAA AGT GGC CTA TAC TAT CTC AGC ACC ACT GTG AAA GAG ATG TCG AAG AAA GCG CCC TCT GAA ATT AGC CGG AAA TAT CAA TCA

Glu

Gln

Gln

Ser

Gly

Leu

Tyr

Tyr

Leu

Ser

Thr

Thr

Val

Lys

Glu

Met

Ser

Lys

Lys

Ala

Pro

Ser

Glu

Ile

Ser

Arg

Lys

Tyr

Gln

Ser

991

992

993

994

995

996

997

998

999

1000

1001

1002

1003

1004

1005

1006

1007

1008

1009

1010

1011

1012

1013

1014

1015

1016

1017

1018

1019

1020
Exon # 23
GAA TTT GAA GAA ATT GAG GGA CGC TGG AAG AAG CTC TCC TCC CAG CTG GTT GAG CAT TGT CAA AAG CTA GAG GAG CAA ATG AAT AAA CTC

Glu

Phe

Glu

Glu

Ile

Glu

Gly

Arg

Trp

Lys

Lys

Leu

Ser

Ser

Gln

Leu

Val

Glu

His

Cys

Gln

Lys

Leu

Glu

Glu

Gln

Met

Asn

Lys

Leu

1021

1022

1023

1024

1025

1026

1027

1028

1029

1030

1031

1032

1033

1034

1035

1036

1037

1038

1039

1040

1041

1042

1043

1044

1045

1046

1047

1048

1049

1050
Exon # 23 Exon # 24
CGA AAA ATT CAG AAT CAC ATA CAA ACC CTG AAG AAA TGG ATG GCT GAA GTT GAT GTT TTT CTG AAG GAG GAA TGG CCT GCC CTT GGG GAT

Arg

Lys

Ile

Gln

Asn

His

Ile

Gln

Thr

Leu

Lys

Lys

Trp

Met

Ala

Glu

Val

Asp

Val

Phe

Leu

Lys

Glu

Glu

Trp

Pro

Ala

Leu

Gly

Asp

1051

1052

1053

1054

1055

1056

1057

1058

1059

1060

1061

1062

1063

1064

1065

1066

1067

1068

1069

1070

1071

1072

1073

1074

1075

1076

1077

1078

1079

1080
Exon # 24 Exon # 25
TCA GAA ATT CTA AAA AAG CAG CTG AAA CAG TGC AGA CTT TTA GTC AGT GAT ATT CAG ACA ATT CAG CCC AGT CTA AAC AGT GTC AAT GAA

Ser

Glu

Ile

Leu

Lys

Lys

Gln

Leu

Lys

Gln

Cys

Arg

Leu

Leu

Val

Ser

Asp

Ile

Gln

Thr

Ile

Gln

Pro

Ser

Leu

Asn

Ser

Val

Asn

Glu

1081

1082

1083

1084

1085

1086

1087

1088

1089

1090

1091

1092

1093

1094

1095

1096

1097

1098

1099

1100

1101

1102

1103

1104

1105

1106

1107

1108

1109

1110
Exon # 25
GGT GGG CAG AAG ATA AAG AAT GAA GCA GAG CCA GAG TTT GCT TCG AGA CTT GAG ACA GAA CTC AAA GAA CTT AAC ACT CAG TGG GAT CAC

Gly

Gly

Gln

Lys

Ile

Lys

Asn

Glu

Ala

Glu

Pro

Glu

Phe

Ala

Ser

Arg

Leu

Glu

Thr

Glu

Leu

Lys

Glu

Leu

Asn

Thr

Gln

Trp

Asp

His

1111

1112

1113

1114

1115

1116

1117

1118

1119

1120

1121

1122

1123

1124

1125

1126

1127

1128

1129

1130

1131

1132

1133

1134

1135

1136

1137

1138

1139

1140
Exon # 25 Exon # 26
ATG TGC CAA CAG GTC TAT GCC AGA AAG GAG GCC TTG AAG GGA GGT TTG GAG AAA ACT GTA AGC CTC CAG AAA GAT CTA TCA GAG ATG CAC

Met

Cys

Gln

Gln

Val

Tyr

Ala

Arg

Lys

Glu

Ala

Leu

Lys

Gly

Gly

Leu

Glu

Lys

Thr

Val

Ser

Leu

Gln

Lys

Asp

Leu

Ser

Glu

Met

His

1141

1142

1143

1144

1145

1146

1147

1148

1149

1150

1151

1152

1153

1154

1155

1156

1157

1158

1159

1160

1161

1162

1163

1164

1165

1166

1167

1168

1169

1170
Exon # 26
GAA TGG ATG ACA CAA GCT GAA GAA GAG TAT CTT GAG AGA GAT TTT GAA TAT AAA ACT CCA GAT GAA TTA CAG AAA GCA GTT GAA GAG ATG

Glu

Trp

Met

Thr

Gln

Ala

Glu

Glu

Glu

Tyr

Leu

Glu

Arg

Asp

Phe

Glu

Tyr

Lys

Thr

Pro

Asp

Glu

Leu

Gln

Lys

Ala

Val

Glu

Glu

Met

1171

1172

1173

1174

1175

1176

1177

1178

1179

1180

1181

1182

1183

1184

1185

1186

1187

1188

1189

1190

1191

1192

1193

1194

1195

1196

1197

1198

1199

1200
  Exon # 27
AAG AGA GCT AAA GAA GAG GCC CAA CAA AAA GAA GCG AAA GTG AAA CTC CTT ACT GAG TCT GTA AAT AGT GTC ATA GCT CAA GCT CCA CCT

Lys

Arg

Ala

Lys

Glu

Glu

Ala

Gln

Gln

Lys

Glu

Ala

Lys

Val

Lys

Leu

Leu

Thr

Glu

Ser

Val

Asn

Ser

Val

Ile

Ala

Gln

Ala

Pro

Pro

1201

1202

1203

1204

1205

1206

1207

1208

1209

1210

1211

1212

1213

1214

1215

1216

1217

1218

1219

1220

1221

1222

1223

1224

1225

1226

1227

1228

1229

1230
Exon # 27
GTA GCA CAA GAG GCC TTA AAA AAG GAA CTT GAA ACT CTA ACC ACC AAC TAC CAG TGG CTC TGC ACT AGG CTG AAT GGG AAA TGC AAG ACT

Val

Ala

Gln

Glu

Ala

Leu

Lys

Lys

Glu

Leu

Glu

Thr

Leu

Thr

Thr

Asn

Tyr

Gln

Trp

Leu

Cys

Thr

Arg

Leu

Asn

Gly

Lys

Cys

Lys

Thr

1231

1232

1233

1234

1235

1236

1237

1238

1239

1240

1241

1242

1243

1244

1245

1246

1247

1248

1249

1250

1251

1252

1253

1254

1255

1256

1257

1258

1259

1260
Exon # 27 Exon # 28
TTG GAA GAA GTT TGG GCA TGT TGG CAT GAG TTA TTG TCA TAC TTG GAG AAA GCA AAC AAG TGG CTA AAT GAA GTA GAA TTT AAA CTT AAA

Leu

Glu

Glu

Val

Trp

Ala

Cys

Trp

His

Glu

Leu

Leu

Ser

Tyr

Leu

Glu

Lys

Ala

Asn

Lys

Trp

Leu

Asn

Glu

Val

Glu

Phe

Lys

Leu

Lys

1261

1262

1263

1264

1265

1266

1267

1268

1269

1270

1271

1272

1273

1274

1275

1276

1277

1278

1279

1280

1281

1282

1283

1284

1285

1286

1287

1288

1289

1290
Exon # 28 Exon # 29
ACC ACT GAA AAC ATT CCT GGC GGA GCT GAG GAA ATC TCT GAG GTG CTA GAT TCA CTT GAA AAT TTG ATG CGA CAT TCA GAG GAT AAC CCA

Thr

Thr

Glu

Asn

Ile

Pro

Gly

Gly

Ala

Glu

Glu

Ile

Ser

Glu

Val

Leu

Asp

Ser

Leu

Glu

Asn

Leu

Met

Arg

His

Ser

Glu

Asp

Asn

Pro

1291

1292

1293

1294

1295

1296

1297

1298

1299

1300

1301

1302

1303

1304

1305

1306

1307

1308

1309

1310

1311

1312

1313

1314

1315

1316

1317

1318

1319

1320
Exon # 29
AAT CAG ATT CGC ATA TTG GCA CAG ACC CTA ACA GAT GGC GGA GTC ATG GAT GAG CTA ATC AAT GAG GAA CTT GAG ACA TTT AAT TCT CGT

Asn

Gln

Ile

Arg

Ile

Leu

Ala

Gln

Thr

Leu

Thr

Asp

Gly

Gly

Val

Met

Asp

Glu

Leu

Ile

Asn

Glu

Glu

Leu

Glu

Thr

Phe

Asn

Ser

Arg

1321

1322

1323

1324

1325

1326

1327

1328

1329

1330

1331

1332

1333

1334

1335

1336

1337

1338

1339

1340

1341

1342

1343

1344

1345

1346

1347

1348

1349

1350
Exon # 29 Exon # 30
TGG AGG GAA CTA CAT GAA GAG GCT GTA AGG AGG CAA AAG TTG CTT GAA CAG AGC ATC CAG TCT GCC CAG GAG ACT GAA AAA TCC TTA CAC

Trp

Arg

Glu

Leu

His

Glu

Glu

Ala

Val

Arg

Arg

Gln

Lys

Leu

Leu

Glu

Gln

Ser

Ile

Gln

Ser

Ala

Gln

Glu

Thr

Glu

Lys

Ser

Leu

His

1351

1352

1353

1354

1355

1356

1357

1358

1359

1360

1361

1362

1363

1364

1365

1366

1367

1368

1369

1370

1371

1372

1373

1374

1375

1376

1377

1378

1379

1380
Exon # 30
TTA ATC CAG GAG TCC CTC ACA TTC ATT GAC AAG CAG TTG GCA GCT TAT ATT GCA GAC AAG GTG GAC GCA GCT CAA ATG CCT CAG GAA GCC

Leu

Ile

Gln

Glu

Ser

Leu

Thr

Phe

Ile

Asp

Lys

Gln

Leu

Ala

Ala

Tyr

Ile

Ala

Asp

Lys

Val

Asp

Ala

Ala

Gln

Met

Pro

Gln

Glu

Ala

1381

1382

1383

1384

1385

1386

1387

1388

1389

1390

1391

1392

1393

1394

1395

1396

1397

1398

1399

1400

1401

1402

1403

1404

1405

1406

1407

1408

1409

1410
  Exon # 31
CAG AAA ATC CAA TCT GAT TTG ACA AGT CAT GAG ATC AGT TTA GAA GAA ATG AAG AAA CAT AAT CAG GGG AAG GAG GCT GCC CAA AGA GTC

Gln

Lys

Ile

Gln

Ser

Asp

Leu

Thr

Ser

His

Glu

Ile

Ser

Leu

Glu

Glu

Met

Lys

Lys

His

Asn

Gln

Gly

Lys

Glu

Ala

Ala

Gln

Arg

Val

1411

1412

1413

1414

1415

1416

1417

1418

1419

1420

1421

1422

1423

1424

1425

1426

1427

1428

1429

1430

1431

1432

1433

1434

1435

1436

1437

1438

1439

1440
Exon # 31 Exon # 32
CTG TCT CAG ATT GAT GTT GCA CAG AAA AAA TTA CAA GAT GTC TCC ATG AAG TTT CGA TTA TTC CAG AAA CCA GCC AAT TTT GAG CAG CGT

Leu

Ser

Gln

Ile

Asp

Val

Ala

Gln

Lys

Lys

Leu

Gln

Asp

Val

Ser

Met

Lys

Phe

Arg

Leu

Phe

Gln

Lys

Pro

Ala

Asn

Phe

Glu

Gln

Arg

1441

1442

1443

1444

1445

1446

1447

1448

1449

1450

1451

1452

1453

1454

1455

1456

1457

1458

1459

1460

1461

1462

1463

1464

1465

1466

1467

1468

1469

1470
Exon # 32
CTA CAA GAA AGT AAG ATG ATT TTA GAT GAA GTG AAG ATG CAC TTG CCT GCA TTG GAA ACA AAG AGT GTG GAA CAG GAA GTA GTA CAG TCA

Leu

Gln

Glu

Ser

Lys

Met

Ile

Leu

Asp

Glu

Val

Lys

Met

His

Leu

Pro

Ala

Leu

Glu

Thr

Lys

Ser

Val

Glu

Gln

Glu

Val

Val

Gln

Ser

1471

1472

1473

1474

1475

1476

1477

1478

1479

1480

1481

1482

1483

1484

1485

1486

1487

1488

1489

1490

1491

1492

1493

1494

1495

1496

1497

1498

1499

1500
Exon # 32 Exon # 33
CAG CTA AAT CAT TGT GTG AAC TTG TAT AAA AGT CTG AGT GAA GTG AAG TCT GAA GTG GAA ATG GTG ATA AAG ACT GGA CGT CAG ATT GTA

Gln

Leu

Asn

His

Cys

Val

Asn

Leu

Tyr

Lys

Ser

Leu

Ser

Glu

Val

Lys

Ser

Glu

Val

Glu

Met

Val

Ile

Lys

Thr

Gly

Arg

Gln

Ile

Val

1501

1502

1503

1504

1505

1506

1507

1508

1509

1510

1511

1512

1513

1514

1515

1516

1517

1518

1519

1520

1521

1522

1523

1524

1525

1526

1527

1528

1529

1530
Exon # 33 Exon # 34
CAG AAA AAG CAG ACG GAA AAT CCC AAA GAA CTT GAT GAA AGA GTA ACA GCT TTG AAA TTG CAT TAT AAT GAG CTG GGA GCA AAG GTA ACA

Gln

Lys

Lys

Gln

Thr

Glu

Asn

Pro

Lys

Glu

Leu

Asp

Glu

Arg

Val

Thr

Ala

Leu

Lys

Leu

His

Tyr

Asn

Glu

Leu

Gly

Ala

Lys

Val

Thr

1531

1532

1533

1534

1535

1536

1537

1538

1539

1540

1541

1542

1543

1544

1545

1546

1547

1548

1549

1550

1551

1552

1553

1554

1555

1556

1557

1558

1559

1560
Exon # 34
GAA AGA AAG CAA CAG TTG GAG AAA TGC TTG AAA TTG TCC CGT AAG ATG CGA AAG GAA ATG AAT GTC TTG ACA GAA TGG CTG GCA GCT ACA

Glu

Arg

Lys

Gln

Gln

Leu

Glu

Lys

Cys

Leu

Lys

Leu

Ser

Arg

Lys

Met

Arg

Lys

Glu

Met

Asn

Val

Leu

Thr

Glu

Trp

Leu

Ala

Ala

Thr

1561

1562

1563

1564

1565

1566

1567

1568

1569

1570

1571

1572

1573

1574

1575

1576

1577

1578

1579

1580

1581

1582

1583

1584

1585

1586

1587

1588

1589

1590
Exon # 34 Exon # 35
GAT ATG GAA TTG ACA AAG AGA TCA GCA GTT GAA GGA ATG CCT AGT AAT TTG GAT TCT GAA GTT GCC TGG GGA AAG GCT ACT CAA AAA GAG

Asp

Met

Glu

Leu

Thr

Lys

Arg

Ser

Ala

Val

Glu

Gly

Met

Pro

Ser

Asn

Leu

Asp

Ser

Glu

Val

Ala

Trp

Gly

Lys

Ala

Thr

Gln

Lys

Glu

1591

1592

1593

1594

1595

1596

1597

1598

1599

1600

1601

1602

1603

1604

1605

1606

1607

1608

1609

1610

1611

1612

1613

1614

1615

1616

1617

1618

1619

1620
Exon # 35
ATT GAG AAA CAG AAG GTG CAC CTG AAG AGT ATC ACA GAG GTA GGA GAG GCC TTG AAA ACA GTT TTG GGC AAG AAG GAG ACG TTG GTG GAA

Ile

Glu

Lys

Gln

Lys

Val

His

Leu

Lys

Ser

Ile

Thr

Glu

Val

Gly

Glu

Ala

Leu

Lys

Thr

Val

Leu

Gly

Lys

Lys

Glu

Thr

Leu

Val

Glu

1621

1622

1623

1624

1625

1626

1627

1628

1629

1630

1631

1632

1633

1634

1635

1636

1637

1638

1639

1640

1641

1642

1643

1644

1645

1646

1647

1648

1649

1650
Exon # 35 Exon # 36
GAT AAA CTC AGT CTT CTG AAT AGT AAC TGG ATA GCT GTC ACC TCC CGA GCA GAA GAG TGG TTA AAT CTT TTG TTG GAA TAC CAG AAA CAC

Asp

Lys

Leu

Ser

Leu

Leu

Asn

Ser

Asn

Trp

Ile

Ala

Val

Thr

Ser

Arg

Ala

Glu

Glu

Trp

Leu

Asn

Leu

Leu

Leu

Glu

Tyr

Gln

Lys

His

1651

1652

1653

1654

1655

1656

1657

1658

1659

1660

1661

1662

1663

1664

1665

1666

1667

1668

1669

1670

1671

1672

1673

1674

1675

1676

1677

1678

1679

1680
Exon # 36
ATG GAA ACT TTT GAC CAG AAT GTG GAC CAC ATC ACA AAG TGG ATC ATT CAG GCT GAC ACA CTT TTG GAT GAA TCA GAG AAA AAG AAA CCC

Met

Glu

Thr

Phe

Asp

Gln

Asn

Val

Asp

His

Ile

Thr

Lys

Trp

Ile

Ile

Gln

Ala

Asp

Thr

Leu

Leu

Asp

Glu

Ser

Glu

Lys

Lys

Lys

Pro

1681

1682

1683

1684

1685

1686

1687

1688

1689

1690

1691

1692

1693

1694

1695

1696

1697

1698

1699

1700

1701

1702

1703

1704

1705

1706

1707

1708

1709

1710
Exon # 36 Exon # 37
CAG CAA AAA GAA GAC GTG CTT AAG CGT TTA AAG GCA GAA CTG AAT GAC ATA CGC CCA AAG GTG GAC TCT ACA CGT GAC CAA GCA GCA AAC

Gln

Gln

Lys

Glu

Asp

Val

Leu

Lys

Arg

Leu

Lys

Ala

Glu

Leu

Asn

Asp

Ile

Arg

Pro

Lys

Val

Asp

Ser

Thr

Arg

Asp

Gln

Ala

Ala

Asn

1711

1712

1713

1714

1715

1716

1717

1718

1719

1720

1721

1722

1723

1724

1725

1726

1727

1728

1729

1730

1731

1732

1733

1734

1735

1736

1737

1738

1739

1740
Exon # 37
TTG ATG GCA AAC CGC GGT GAC CAC TGC AGG AAA TTA GTA GAG CCC CAA ATC TCA GAG CTC AAC CAT CGA TTT GCA GCC ATT TCA CAC AGA

Leu

Met

Ala

Asn

Arg

Gly

Asp

His

Cys

Arg

Lys

Leu

Val

Glu

Pro

Gln

Ile

Ser

Glu

Leu

Asn

His

Arg

Phe

Ala

Ala

Ile

Ser

His

Arg

1741

1742

1743

1744

1745

1746

1747

1748

1749

1750

1751

1752

1753

1754

1755

1756

1757

1758

1759

1760

1761

1762

1763

1764

1765

1766

1767

1768

1769

1770
Exon # 37 Exon # 38
ATT AAG ACT GGA AAG GCC TCC ATT CCT TTG AAG GAA TTG GAG CAG TTT AAC TCA GAT ATA CAA AAA TTG CTT GAA CCA CTG GAG GCT GAA

Ile

Lys

Thr

Gly

Lys

Ala

Ser

Ile

Pro

Leu

Lys

Glu

Leu

Glu

Gln

Phe

Asn

Ser

Asp

Ile

Gln

Lys

Leu

Leu

Glu

Pro

Leu

Glu

Ala

Glu

1771

1772

1773

1774

1775

1776

1777

1778

1779

1780

1781

1782

1783

1784

1785

1786

1787

1788

1789

1790

1791

1792

1793

1794

1795

1796

1797

1798

1799

1800
Exon # 38 Exon # 39
ATT CAG CAG GGG GTG AAT CTG AAA GAG GAA GAC TTC AAT AAA GAT ATG AAT GAA GAC AAT GAG GGT ACT GTA AAA GAA TTG TTG CAA AGA

Ile

Gln

Gln

Gly

Val

Asn

Leu

Lys

Glu

Glu

Asp

Phe

Asn

Lys

Asp

Met

Asn

Glu

Asp

Asn

Glu

Gly

Thr

Val

Lys

Glu

Leu

Leu

Gln

Arg

1801

1802

1803

1804

1805

1806

1807

1808

1809

1810

1811

1812

1813

1814

1815

1816

1817

1818

1819

1820

1821

1822

1823

1824

1825

1826

1827

1828

1829

1830
Exon # 39
GGA GAC AAC TTA CAA CAA AGA ATC ACA GAT GAG AGA AAG CGA GAG GAA ATA AAG ATA AAA CAG CAG CTG TTA CAG ACA AAA CAT AAT GCT

Gly

Asp

Asn

Leu

Gln

Gln

Arg

Ile

Thr

Asp

Glu

Arg

Lys

Arg

Glu

Glu

Ile

Lys

Ile

Lys

Gln

Gln

Leu

Leu

Gln

Thr

Lys

His

Asn

Ala

1831

1832

1833

1834

1835

1836

1837

1838

1839

1840

1841

1842

1843

1844

1845

1846

1847

1848

1849

1850

1851

1852

1853

1854

1855

1856

1857

1858

1859

1860
Exon # 39 Exon # 40
CTC AAG GAT TTG AGG TCT CAA AGA AGA AAA AAG GCT CTA GAA ATT TCT CAT CAG TGG TAT CAG TAC AAG AGG CAG GCT GAT GAT CTC CTG

Leu

Lys

Asp

Leu

Arg

Ser

Gln

Arg

Arg

Lys

Lys

Ala

Leu

Glu

Ile

Ser

His

Gln

Trp

Tyr

Gln

Tyr

Lys

Arg

Gln

Ala

Asp

Asp

Leu

Leu

1861

1862

1863

1864

1865

1866

1867

1868

1869

1870

1871

1872

1873

1874

1875

1876

1877

1878

1879

1880

1881

1882

1883

1884

1885

1886

1887

1888

1889

1890
Exon # 40 Exon # 41
AAA TGC TTG GAT GAC ATT GAA AAA AAA TTA GCC AGC CTA CCT GAG CCC AGA GAT GAA AGG AAA ATA AAG GAA ATT GAT CGG GAA TTG CAG

Lys

Cys

Leu

Asp

Asp

Ile

Glu

Lys

Lys

Leu

Ala

Ser

Leu

Pro

Glu

Pro

Arg

Asp

Glu

Arg

Lys

Ile

Lys

Glu

Ile

Asp

Arg

Glu

Leu

Gln

1891

1892

1893

1894

1895

1896

1897

1898

1899

1900

1901

1902

1903

1904

1905

1906

1907

1908

1909

1910

1911

1912

1913

1914

1915

1916

1917

1918

1919

1920
Exon # 41
AAG AAG AAA GAG GAG CTG AAT GCA GTG CGT AGG CAA GCT GAG GGC TTG TCT GAG GAT GGG GCC GCA ATG GCA GTG GAG CCA ACT CAG ATC

Lys

Lys

Lys

Glu

Glu

Leu

Asn

Ala

Val

Arg

Arg

Gln

Ala

Glu

Gly

Leu

Ser

Glu

Asp

Gly

Ala

Ala

Met

Ala

Val

Glu

Pro

Thr

Gln

Ile

1921

1922

1923

1924

1925

1926

1927

1928

1929

1930

1931

1932

1933

1934

1935

1936

1937

1938

1939

1940

1941

1942

1943

1944

1945

1946

1947

1948

1949

1950
Exon # 41 Exon # 42
CAG CTC AGC AAG CGC TGG CGG GAA ATT GAG AGC AAA TTT GCT CAG TTT CGA AGA CTC AAC TTT GCA CAA ATT CAC ACT GTC CGT GAA GAA

Gln

Leu

Ser

Lys

Arg

Trp

Arg

Glu

Ile

Glu

Ser

Lys

Phe

Ala

Gln

Phe

Arg

Arg

Leu

Asn

Phe

Ala

Gln

Ile

His

Thr

Val

Arg

Glu

Glu

1951

1952

1953

1954

1955

1956

1957

1958

1959

1960

1961

1962

1963

1964

1965

1966

1967

1968

1969

1970

1971

1972

1973

1974

1975

1976

1977

1978

1979

1980
Exon # 42
ACG ATG ATG GTG ATG ACT GAA GAC ATG CCT TTG GAA ATT TCT TAT GTG CCT TCT ACT TAT TTG ACT GAA ATC ACT CAT GTC TCA CAA GCC

Thr

Met

Met

Val

Met

Thr

Glu

Asp

Met

Pro

Leu

Glu

Ile

Ser

Tyr

Val

Pro

Ser

Thr

Tyr

Leu

Thr

Glu

Ile

Thr

His

Val

Ser

Gln

Ala

1981

1982

1983

1984

1985

1986

1987

1988

1989

1990

1991

1992

1993

1994

1995

1996

1997

1998

1999

2000

2001

2002

2003

2004

2005

2006

2007

2008

2009

2010
Exon # 42  
CTA TTA GAA GTG GAA CAA CTT CTC AAT GCT CCT GAC CTC TGT GCT AAG GAC TTT GAA GAT CTC TTT AAG CAA GAG GAG TCT CTG AAG AAT

Leu

Leu

Glu

Val

Glu

Gln

Leu

Leu

Asn

Ala

Pro

Asp

Leu

Cys

Ala

Lys

Asp

Phe

Glu

Asp

Leu

Phe

Lys

Gln

Glu

Glu

Ser

Leu

Lys

Asn

2011

2012

2013

2014

2015

2016

2017

2018

2019

2020

2021

2022

2023

2024

2025

2026

2027

2028

2029

2030

2031

2032

2033

2034

2035

2036

2037

2038

2039

2040
Exon # 43
ATA AAA GAT AGT CTA CAA CAA AGC TCA GGT CGG ATT GAC ATT ATT CAT AGC AAG AAG ACA GCA GCA TTG CAA AGT GCA ACG CCT GTG GAA

Ile

Lys

Asp

Ser

Leu

Gln

Gln

Ser

Ser

Gly

Arg

Ile

Asp

Ile

Ile

His

Ser

Lys

Lys

Thr

Ala

Ala

Leu

Gln

Ser

Ala

Thr

Pro

Val

Glu

2041

2042

2043

2044

2045

2046

2047

2048

2049

2050

2051

2052

2053

2054

2055

2056

2057

2058

2059

2060

2061

2062

2063

2064

2065

2066

2067

2068

2069

2070
Exon # 43 Exon # 44
AGG GTG AAG CTA CAG GAA GCT CTC TCC CAG CTT GAT TTC CAA TGG GAA AAA GTT AAC AAA ATG TAC AAG GAC CGA CAA GGG CGA TTT GAC

Arg

Val

Lys

Leu

Gln

Glu

Ala

Leu

Ser

Gln

Leu

Asp

Phe

Gln

Trp

Glu

Lys

Val

Asn

Lys

Met

Tyr

Lys

Asp

Arg

Gln

Gly

Arg

Phe

Asp

2071

2072

2073

2074

2075

2076

2077

2078

2079

2080

2081

2082

2083

2084

2085

2086

2087

2088

2089

2090

2091

2092

2093

2094

2095

2096

2097

2098

2099

2100
Exon # 44
AGA TCT GTT GAG AAA TGG CGG CGT TTT CAT TAT GAT ATA AAG ATA TTT AAT CAG TGG CTA ACA GAA GCT GAA CAG TTT CTC AGA AAG ACA

Arg

Ser

Val

Glu

Lys

Trp

Arg

Arg

Phe

His

Tyr

Asp

Ile

Lys

Ile

Phe

Asn

Gln

Trp

Leu

Thr

Glu

Ala

Glu

Gln

Phe

Leu

Arg

Lys

Thr

2101

2102

2103

2104

2105

2106

2107

2108

2109

2110

2111

2112

2113

2114

2115

2116

2117

2118

2119

2120

2121

2122

2123

2124

2125

2126

2127

2128

2129

2130
Exon # 44 Exon # 45
CAA ATT CCT GAG AAT TGG GAA CAT GCT AAA TAC AAA TGG TAT CTT AAG GAA CTC CAG GAT GGC ATT GGG CAG CGG CAA ACT GTT GTC AGA

Gln

Ile

Pro

Glu

Asn

Trp

Glu

His

Ala

Lys

Tyr

Lys

Trp

Tyr

Leu

Lys

Glu

Leu

Gln

Asp

Gly

Ile

Gly

Gln

Arg

Gln

Thr

Val

Val

Arg

2131

2132

2133

2134

2135

2136

2137

2138

2139

2140

2141

2142

2143

2144

2145

2146

2147

2148

2149

2150

2151

2152

2153

2154

2155

2156

2157

2158

2159

2160
Exon # 45
ACA TTG AAT GCA ACT GGG GAA GAA ATA ATT CAG CAA TCC TCA AAA ACA GAT GCC AGT ATT CTA CAG GAA AAA TTG GGA AGC CTG AAT CTG

Thr

Leu

Asn

Ala

Thr

Gly

Glu

Glu

Ile

Ile

Gln

Gln

Ser

Ser

Lys

Thr

Asp

Ala

Ser

Ile

Leu

Gln

Glu

Lys

Leu

Gly

Ser

Leu

Asn

Leu

2161

2162

2163

2164

2165

2166

2167

2168

2169

2170

2171

2172

2173

2174

2175

2176

2177

2178

2179

2180

2181

2182

2183

2184

2185

2186

2187

2188

2189

2190
Exon # 45 Exon # 46
CGG TGG CAG GAG GTC TGC AAA CAG CTG TCA GAC AGA AAA AAG AGG CTA GAA GAA CAA AAG AAT ATC TTG TCA GAA TTT CAA AGA GAT TTA

Arg

Trp

Gln

Glu

Val

Cys

Lys

Gln

Leu

Ser

Asp

Arg

Lys

Lys

Arg

Leu

Glu

Glu

Gln

Lys

Asn

Ile

Leu

Ser

Glu

Phe

Gln

Arg

Asp

Leu

2191

2192

2193

2194

2195

2196

2197

2198

2199

2200

2201

2202

2203

2204

2205

2206

2207

2208

2209

2210

2211

2212

2213

2214

2215

2216

2217

2218

2219

2220
Exon # 46
AAT GAA TTT GTT TTA TGG TTG GAG GAA GCA GAT AAC ATT GCT AGT ATC CCA CTT GAA CCT GGA AAA GAG CAG CAA CTA AAA GAA AAG CTT

Asn

Glu

Phe

Val

Leu

Trp

Leu

Glu

Glu

Ala

Asp

Asn

Ile

Ala

Ser

Ile

Pro

Leu

Glu

Pro

Gly

Lys

Glu

Gln

Gln

Leu

Lys

Glu

Lys

Leu

2221

2222

2223

2224

2225

2226

2227

2228

2229

2230

2231

2232

2233

2234

2235

2236

2237

2238

2239

2240

2241

2242

2243

2244

2245

2246

2247

2248

2249

2250
Exon # 46 Exon # 47
GAG CAA GTC AAG TTA CTG GTG GAA GAG TTG CCC CTG CGC CAG GGA ATT CTC AAA CAA TTA AAT GAA ACT GGA GGA CCC GTG CTT GTA AGT

Glu

Gln

Val

Lys

Leu

Leu

Val

Glu

Glu

Leu

Pro

Leu

Arg

Gln

Gly

Ile

Leu

Lys

Gln

Leu

Asn

Glu

Thr

Gly

Gly

Pro

Val

Leu

Val

Ser

2251

2252

2253

2254

2255

2256

2257

2258

2259

2260

2261

2262

2263

2264

2265

2266

2267

2268

2269

2270

2271

2272

2273

2274

2275

2276

2277

2278

2279

2280
Exon # 47 Exon # 48
GCT CCC ATA AGC CCA GAA GAG CAA GAT AAA CTT GAA AAT AAG CTC AAG CAG ACA AAT CTC CAG TGG ATA AAG GTT TCC AGA GCT TTA CCT

Ala

Pro

Ile

Ser

Pro

Glu

Glu

Gln

Asp

Lys

Leu

Glu

Asn

Lys

Leu

Lys

Gln

Thr

Asn

Leu

Gln

Trp

Ile

Lys

Val

Ser

Arg

Ala

Leu

Pro

2281

2282

2283

2284

2285

2286

2287

2288

2289

2290

2291

2292

2293

2294

2295

2296

2297

2298

2299

2300

2301

2302

2303

2304

2305

2306

2307

2308

2309

2310
Exon # 48
GAG AAA CAA GGA GAA ATT GAA GCT CAA ATA AAA GAC CTT GGG CAG CTT GAA AAA AAG CTT GAA GAC CTT GAA GAG CAG TTA AAT CAT CTG

Glu

Lys

Gln

Gly

Glu

Ile

Glu

Ala

Gln

Ile

Lys

Asp

Leu

Gly

Gln

Leu

Glu

Lys

Lys

Leu

Glu

Asp

Leu

Glu

Glu

Gln

Leu

Asn

His

Leu

2311

2312

2313

2314

2315

2316

2317

2318

2319

2320

2321

2322

2323

2324

2325

2326

2327

2328

2329

2330

2331

2332

2333

2334

2335

2336

2337

2338

2339

2340
Exon # 48 Exon # 49
CTG CTG TGG TTA TCT CCT ATT AGG AAT CAG TTG GAA ATT TAT AAC CAA CCA AAC CAA GAA GGA CCA TTT GAC GTT AAG GAA ACT GAA ATA

Leu

Leu

Trp

Leu

Ser

Pro

Ile

Arg

Asn

Gln

Leu

Glu

Ile

Tyr

Asn

Gln

Pro

Asn

Gln

Glu

Gly

Pro

Phe

Asp

Val

Lys

Glu

Thr

Glu

Ile

2341

2342

2343

2344

2345

2346

2347

2348

2349

2350

2351

2352

2353

2354

2355

2356

2357

2358

2359

2360

2361

2362

2363

2364

2365

2366

2367

2368

2369

2370
Exon # 49
GCA GTT CAA GCT AAA CAA CCG GAT GTG GAA GAG ATT TTG TCT AAA GGG CAG CAT TTG TAC AAG GAA AAA CCA GCC ACT CAG CCA GTG AAG

Ala

Val

Gln

Ala

Lys

Gln

Pro

Asp

Val

Glu

Glu

Ile

Leu

Ser

Lys

Gly

Gln

His

Leu

Tyr

Lys

Glu

Lys

Pro

Ala

Thr

Gln

Pro

Val

Lys

2371

2372

2373

2374

2375

2376

2377

2378

2379

2380

2381

2382

2383

2384

2385

2386

2387

2388

2389

2390

2391

2392

2393

2394

2395

2396

2397

2398

2399

2400
Exon # 50
AGG AAG TTA GAA GAT CTG AGC TCT GAG TGG AAG GCG GTA AAC CGT TTA CTT CAA GAG CTG AGG GCA AAG CAG CCT GAC CTA GCT CCT GGA

Arg

Lys

Leu

Glu

Asp

Leu

Ser

Ser

Glu

Trp

Lys

Ala

Val

Asn

Arg

Leu

Leu

Gln

Glu

Leu

Arg

Ala

Lys

Gln

Pro

Asp

Leu

Ala

Pro

Gly

2401

2402

2403

2404

2405

2406

2407

2408

2409

2410

2411

2412

2413

2414

2415

2416

2417

2418

2419

2420

2421

2422

2423

2424

2425

2426

2427

2428

2429

2430
Exon # 50 Exon # 51
CTG ACC ACT ATT GGA GCC TCT CCT ACT CAG ACT GTT ACT CTG GTG ACA CAA CCT GTG GTT ACT AAG GAA ACT GCC ATC TCC AAA CTA GAA

Leu

Thr

Thr

Ile

Gly

Ala

Ser

Pro

Thr

Gln

Thr

Val

Thr

Leu

Val

Thr

Gln

Pro

Val

Val

Thr

Lys

Glu

Thr

Ala

Ile

Ser

Lys

Leu

Glu

2431

2432

2433

2434

2435

2436

2437

2438

2439

2440

2441

2442

2443

2444

2445

2446

2447

2448

2449

2450

2451

2452

2453

2454

2455

2456

2457

2458

2459

2460
Exon # 51
ATG CCA TCT TCC TTG ATG TTG GAG GTA CCT GCT CTG GCA GAT TTC AAC CGG GCT TGG ACA GAA CTT ACC GAC TGG CTT TCT CTG CTT GAT

Met

Pro

Ser

Ser

Leu

Met

Leu

Glu

Val

Pro

Ala

Leu

Ala

Asp

Phe

Asn

Arg

Ala

Trp

Thr

Glu

Leu

Thr

Asp

Trp

Leu

Ser

Leu

Leu

Asp

2461

2462

2463

2464

2465

2466

2467

2468

2469

2470

2471

2472

2473

2474

2475

2476

2477

2478

2479

2480

2481

2482

2483

2484

2485

2486

2487

2488

2489

2490
Exon # 51 Exon # 52
CAA GTT ATA AAA TCA CAG AGG GTG ATG GTG GGT GAC CTT GAG GAT ATC AAC GAG ATG ATC ATC AAG CAG AAG GCA ACA ATG CAG GAT TTG

Gln

Val

Ile

Lys

Ser

Gln

Arg

Val

Met

Val

Gly

Asp

Leu

Glu

Asp

Ile

Asn

Glu

Met

Ile

Ile

Lys

Gln

Lys

Ala

Thr

Met

Gln

Asp

Leu

2491

2492

2493

2494

2495

2496

2497

2498

2499

2500

2501

2502

2503

2504

2505

2506

2507

2508

2509

2510

2511

2512

2513

2514

2515

2516

2517

2518

2519

2520
Exon # 52
GAA CAG AGG CGT CCC CAG TTG GAA GAA CTC ATT ACC GCT GCC CAA AAT TTG AAA AAC AAG ACC AGC AAT CAA GAG GCT AGA ACA ATC ATT

Glu

Gln

Arg

Arg

Pro

Gln

Leu

Glu

Glu

Leu

Ile

Thr

Ala

Ala

Gln

Asn

Leu

Lys

Asn

Lys

Thr

Ser

Asn

Gln

Glu

Ala

Arg

Thr

Ile

Ile

2521

2522

2523

2524

2525

2526

2527

2528

2529

2530

2531

2532

2533

2534

2535

2536

2537

2538

2539

2540

2541

2542

2543

2544

2545

2546

2547

2548

2549

2550
Exon # 52 Exon # 53
ACG GAT CGA ATT GAA AGA ATT CAG AAT CAG TGG GAT GAA GTA CAA GAA CAC CTT CAG AAC CGG AGG CAA CAG TTG AAT GAA ATG TTA AAG

Thr

Asp

Arg

Ile

Glu

Arg

Ile

Gln

Asn

Gln

Trp

Asp

Glu

Val

Gln

Glu

His

Leu

Gln

Asn

Arg

Arg

Gln

Gln

Leu

Asn

Glu

Met

Leu

Lys

2551

2552

2553

2554

2555

2556

2557

2558

2559

2560

2561

2562

2563

2564

2565

2566

2567

2568

2569

2570

2571

2572

2573

2574

2575

2576

2577

2578

2579

2580
Exon # 53
GAT TCA ACA CAA TGG CTG GAA GCT AAG GAA GAA GCT GAG CAG GTC TTA GGA CAG GCC AGA GCC AAG CTT GAG TCA TGG AAG GAG GGT CCC

Asp

Ser

Thr

Gln

Trp

Leu

Glu

Ala

Lys

Glu

Glu

Ala

Glu

Gln

Val

Leu

Gly

Gln

Ala

Arg

Ala

Lys

Leu

Glu

Ser

Trp

Lys

Glu

Gly

Pro

2581

2582

2583

2584

2585

2586

2587

2588

2589

2590

2591

2592

2593

2594

2595

2596

2597

2598

2599

2600

2601

2602

2603

2604

2605

2606

2607

2608

2609

2610
Exon # 53 Exon # 54
TAT ACA GTA GAT GCA ATC CAA AAG AAA ATC ACA GAA ACC AAG CAG TTG GCC AAA GAC CTC CGC CAG TGG CAG ACA AAT GTA GAT GTG GCA

Tyr

Thr

Val

Asp

Ala

Ile

Gln

Lys

Lys

Ile

Thr

Glu

Thr

Lys

Gln

Leu

Ala

Lys

Asp

Leu

Arg

Gln

Trp

Gln

Thr

Asn

Val

Asp

Val

Ala

2611

2612

2613

2614

2615

2616

2617

2618

2619

2620

2621

2622

2623

2624

2625

2626

2627

2628

2629

2630

2631

2632

2633

2634

2635

2636

2637

2638

2639

2640
Exon # 54
AAT GAC TTG GCC CTG AAA CTT CTC CGG GAT TAT TCT GCA GAT GAT ACC AGA AAA GTC CAC ATG ATA ACA GAG AAT ATC AAT GCC TCT TGG

Asn

Asp

Leu

Ala

Leu

Lys

Leu

Leu

Arg

Asp

Tyr

Ser

Ala

Asp

Asp

Thr

Arg

Lys

Val

His

Met

Ile

Thr

Glu

Asn

Ile

Asn

Ala

Ser

Trp

2641

2642

2643

2644

2645

2646

2647

2648

2649

2650

2651

2652

2653

2654

2655

2656

2657

2658

2659

2660

2661

2662

2663

2664

2665

2666

2667

2668

2669

2670
Exon # 54 Exon # 55
AGA AGC ATT CAT AAA AGG GTG AGT GAG CGA GAG GCT GCT TTG GAA GAA ACT CAT AGA TTA CTG CAA CAG TTC CCC CTG GAC CTG GAA AAG

Arg

Ser

Ile

His

Lys

Arg

Val

Ser

Glu

Arg

Glu

Ala

Ala

Leu

Glu

Glu

Thr

His

Arg

Leu

Leu

Gln

Gln

Phe

Pro

Leu

Asp

Leu

Glu

Lys

2671

2672

2673

2674

2675

2676

2677

2678

2679

2680

2681

2682

2683

2684

2685

2686

2687

2688

2689

2690

2691

2692

2693

2694

2695

2696

2697

2698

2699

2700
Exon # 55
TTT CTT GCC TGG CTT ACA GAA GCT GAA ACA ACT GCC AAT GTC CTA CAG GAT GCT ACC CGT AAG GAA AGG CTC CTA GAA GAC TCC AAG GGA

Phe

Leu

Ala

Trp

Leu

Thr

Glu

Ala

Glu

Thr

Thr

Ala

Asn

Val

Leu

Gln

Asp

Ala

Thr

Arg

Lys

Glu

Arg

Leu

Leu

Glu

Asp

Ser

Lys

Gly

2701

2702

2703

2704

2705

2706

2707

2708

2709

2710

2711

2712

2713

2714

2715

2716

2717

2718

2719

2720

2721

2722

2723

2724

2725

2726

2727

2728

2729

2730
Exon # 55 Exon # 56
GTA AAA GAG CTG ATG AAA CAA TGG CAA GAC CTC CAA GGT GAA ATT GAA GCT CAC ACA GAT GTT TAT CAC AAC CTG GAT GAA AAC AGC CAA

Val

Lys

Glu

Leu

Met

Lys

Gln

Trp

Gln

Asp

Leu

Gln

Gly

Glu

Ile

Glu

Ala

His

Thr

Asp

Val

Tyr

His

Asn

Leu

Asp

Glu

Asn

Ser

Gln

2731

2732

2733

2734

2735

2736

2737

2738

2739

2740

2741

2742

2743

2744

2745

2746

2747

2748

2749

2750

2751

2752

2753

2754

2755

2756

2757

2758

2759

2760
Exon # 56
AAA ATC CTG AGA TCC CTG GAA GGT TCC GAT GAT GCA GTC CTG TTA CAA AGA CGT TTG GAT AAC ATG AAC TTC AAG TGG AGT GAA CTT CGG

Lys

Ile

Leu

Arg

Ser

Leu

Glu

Gly

Ser

Asp

Asp

Ala

Val

Leu

Leu

Gln

Arg

Arg

Leu

Asp

Asn

Met

Asn

Phe

Lys

Trp

Ser

Glu

Leu

Arg

2761

2762

2763

2764

2765

2766

2767

2768

2769

2770

2771

2772

2773

2774

2775

2776

2777

2778

2779

2780

2781

2782

2783

2784

2785

2786

2787

2788

2789

2790
Exon # 56 Exon # 57
AAA AAG TCT CTC AAC ATT AGG TCC CAT TTG GAA GCC AGT TCT GAC CAG TGG AAG CGT CTG CAC CTT TCT CTG CAG GAA CTT CTG GTG TGG

Lys

Lys

Ser

Leu

Asn

Ile

Arg

Ser

His

Leu

Glu

Ala

Ser

Ser

Asp

Gln

Trp

Lys

Arg

Leu

His

Leu

Ser

Leu

Gln

Glu

Leu

Leu

Val

Trp

2791

2792

2793

2794

2795

2796

2797

2798

2799

2800

2801

2802

2803

2804

2805

2806

2807

2808

2809

2810

2811

2812

2813

2814

2815

2816

2817

2818

2819

2820
Exon # 57  
CTA CAG CTG AAA GAT GAT GAA TTA AGC CGG CAG GCA CCT ATT GGA GGC GAC TTT CCA GCA GTT CAG AAG CAG AAC GAT GTA CAT AGG GCC

Leu

Gln

Leu

Lys

Asp

Asp

Glu

Leu

Ser

Arg

Gln

Ala

Pro

Ile

Gly

Gly

Asp

Phe

Pro

Ala

Val

Gln

Lys

Gln

Asn

Asp

Val

His

Arg

Ala

2821

2822

2823

2824

2825

2826

2827

2828

2829

2830

2831

2832

2833

2834

2835

2836

2837

2838

2839

2840

2841

2842

2843

2844

2845

2846

2847

2848

2849

2850
Exon # 58
TTC AAG AGG GAA TTG AAA ACT AAA GAA CCT GTA ATC ATG AGT ACT CTT GAG ACT GTA CGA ATA TTT CTG ACA GAG CAG CCT TTG GAA GGA

Phe

Lys

Arg

Glu

Leu

Lys

Thr

Lys

Glu

Pro

Val

Ile

Met

Ser

Thr

Leu

Glu

Thr

Val

Arg

Ile

Phe

Leu

Thr

Glu

Gln

Pro

Leu

Glu

Gly

2851

2852

2853

2854

2855

2856

2857

2858

2859

2860

2861

2862

2863

2864

2865

2866

2867

2868

2869

2870

2871

2872

2873

2874

2875

2876

2877

2878

2879

2880
Exon # 58 Exon # 59
CTA GAG AAA CTC TAC CAG GAG CCC AGA GAG CTG CCT CCT GAG GAG AGA GCC CAG AAT GTC ACT CGG CTT CTA CGA AAG CAG GCT GAG GAG

Leu

Glu

Lys

Leu

Tyr

Gln

Glu

Pro

Arg

Glu

Leu

Pro

Pro

Glu

Glu

Arg

Ala

Gln

Asn

Val

Thr

Arg

Leu

Leu

Arg

Lys

Gln

Ala

Glu

Glu

2881

2882

2883

2884

2885

2886

2887

2888

2889

2890

2891

2892

2893

2894

2895

2896

2897

2898

2899

2900

2901

2902

2903

2904

2905

2906

2907

2908

2909

2910
Exon # 59
GTC AAT ACT GAG TGG GAA AAA TTG AAC CTG CAC TCC GCT GAC TGG CAG AGA AAA ATA GAT GAG ACC CTT GAA AGA CTC CGG GAA CTT CAA

Val

Asn

Thr

Glu

Trp

Glu

Lys

Leu

Asn

Leu

His

Ser

Ala

Asp

Trp

Gln

Arg

Lys

Ile

Asp

Glu

Thr

Leu

Glu

Arg

Leu

Arg

Glu

Leu

Gln

2911

2912

2913

2914

2915

2916

2917

2918

2919

2920

2921

2922

2923

2924

2925

2926

2927

2928

2929

2930

2931

2932

2933

2934

2935

2936

2937

2938

2939

2940
Exon # 59
GAG GCC ACG GAT GAG CTG GAC CTC AAG CTG CGC CAA GCT GAG GTG ATC AAG GGA TCC TGG CAG CCC GTG GGC GAT CTC CTC ATT GAC TCT

Glu

Ala

Thr

Asp

Glu

Leu

Asp

Leu

Lys

Leu

Arg

Gln

Ala

Glu

Val

Ile

Lys

Gly

Ser

Trp

Gln

Pro

Val

Gly

Asp

Leu

Leu

Ile

Asp

Ser

2941

2942

2943

2944

2945

2946

2947

2948

2949

2950

2951

2952

2953

2954

2955

2956

2957

2958

2959

2960

2961

2962

2963

2964

2965

2966

2967

2968

2969

2970
Exon # 59 Exon # 60
CTC CAA GAT CAC CTC GAG AAA GTC AAG GCA CTT CGA GGA GAA ATT GCG CCT CTG AAA GAG AAC GTG AGC CAC GTC AAT GAC CTT GCT CGC

Leu

Gln

Asp

His

Leu

Glu

Lys

Val

Lys

Ala

Leu

Arg

Gly

Glu

Ile

Ala

Pro

Leu

Lys

Glu

Asn

Val

Ser

His

Val

Asn

Asp

Leu

Ala

Arg

2971

2972

2973

2974

2975

2976

2977

2978

2979

2980

2981

2982

2983

2984

2985

2986

2987

2988

2989

2990

2991

2992

2993

2994

2995

2996

2997

2998

2999

3000
Exon # 60 Exon # 61
CAG CTT ACC ACT TTG GGC ATT CAG CTC TCA CCG TAT AAC CTC AGC ACT CTG GAA GAC CTG AAC ACC AGA TGG AAG CTT CTG CAG GTG GCC

Gln

Leu

Thr

Thr

Leu

Gly

Ile

Gln

Leu

Ser

Pro

Tyr

Asn

Leu

Ser

Thr

Leu

Glu

Asp

Leu

Asn

Thr

Arg

Trp

Lys

Leu

Leu

Gln

Val

Ala

3001

3002

3003

3004

3005

3006

3007

3008

3009

3010

3011

3012

3013

3014

3015

3016

3017

3018

3019

3020

3021

3022

3023

3024

3025

3026

3027

3028

3029

3030
Exon # 61 Exon # 62
GTC GAG GAC CGA GTC AGG CAG CTG CAT GAA GCC CAC AGG GAC TTT GGT CCA GCA TCT CAG CAC TTT CTT TCC ACG TCT GTC CAG GGT CCC

Val

Glu

Asp

Arg

Val

Arg

Gln

Leu

His

Glu

Ala

His

Arg

Asp

Phe

Gly

Pro

Ala

Ser

Gln

His

Phe

Leu

Ser

Thr

Ser

Val

Gln

Gly

Pro

3031

3032

3033

3034

3035

3036

3037

3038

3039

3040

3041

3042

3043

3044

3045

3046

3047

3048

3049

3050

3051

3052

3053

3054

3055

3056

3057

3058

3059

3060
Exon # 62 Exon # 63
TGG GAG AGA GCC ATC TCG CCA AAC AAA GTG CCC TAC TAT ATC AAC CAC GAG ACT CAA ACA ACT TGC TGG GAC CAT CCC AAA ATG ACA GAG

Trp

Glu

Arg

Ala

Ile

Ser

Pro

Asn

Lys

Val

Pro

Tyr

Tyr

Ile

Asn

His

Glu

Thr

Gln

Thr

Thr

Cys

Trp

Asp

His

Pro

Lys

Met

Thr

Glu

3061

3062

3063

3064

3065

3066

3067

3068

3069

3070

3071

3072

3073

3074

3075

3076

3077

3078

3079

3080

3081

3082

3083

3084

3085

3086

3087

3088

3089

3090
Exon # 63 Exon # 64
CTC TAC CAG TCT TTA GCT GAC CTG AAT AAT GTC AGA TTC TCA GCT TAT AGG ACT GCC ATG AAA CTC CGA AGA CTG CAG AAG GCC CTT TGC

Leu

Tyr

Gln

Ser

Leu

Ala

Asp

Leu

Asn

Asn

Val

Arg

Phe

Ser

Ala

Tyr

Arg

Thr

Ala

Met

Lys

Leu

Arg

Arg

Leu

Gln

Lys

Ala

Leu

Cys

3091

3092

3093

3094

3095

3096

3097

3098

3099

3100

3101

3102

3103

3104

3105

3106

3107

3108

3109

3110

3111

3112

3113

3114

3115

3116

3117

3118

3119

3120
  Exon # 65
TTG GAT CTC TTG AGC CTG TCA GCT GCA TGT GAT GCC TTG GAC CAG CAC AAC CTC AAG CAA AAT GAC CAG CCC ATG GAT ATC CTG CAG ATT

Leu

Asp

Leu

Leu

Ser

Leu

Ser

Ala

Ala

Cys

Asp

Ala

Leu

Asp

Gln

His

Asn

Leu

Lys

Gln

Asn

Asp

Gln

Pro

Met

Asp

Ile

Leu

Gln

Ile

3121

3122

3123

3124

3125

3126

3127

3128

3129

3130

3131

3132

3133

3134

3135

3136

3137

3138

3139

3140

3141

3142

3143

3144

3145

3146

3147

3148

3149

3150
Exon # 65
ATT AAT TGT TTG ACC ACT ATT TAT GAC CGC CTG GAG CAA GAG CAC AAC AAT TTG GTC AAC GTC CCT CTC TGC GTG GAT ATG TGT CTG AAC

Ile

Asn

Cys

Leu

Thr

Thr

Ile

Tyr

Asp

Arg

Leu

Glu

Gln

Glu

His

Asn

Asn

Leu

Val

Asn

Val

Pro

Leu

Cys

Val

Asp

Met

Cys

Leu

Asn

3151

3152

3153

3154

3155

3156

3157

3158

3159

3160

3161

3162

3163

3164

3165

3166

3167

3168

3169

3170

3171

3172

3173

3174

3175

3176

3177

3178

3179

3180
Exon # 65 Exon # 66
TGG CTG CTG AAT GTT TAT GAT ACG GGA CGA ACA GGG AGG ATC CGT GTC CTG TCT TTT AAA ACT GGC ATC ATT TCC CTG TGT AAA GCA CAT

Trp

Leu

Leu

Asn

Val

Tyr

Asp

Thr

Gly

Arg

Thr

Gly

Arg

Ile

Arg

Val

Leu

Ser

Phe

Lys

Thr

Gly

Ile

Ile

Ser

Leu

Cys

Lys

Ala

His

3181

3182

3183

3184

3185

3186

3187

3188

3189

3190

3191

3192

3193

3194

3195

3196

3197

3198

3199

3200

3201

3202

3203

3204

3205

3206

3207

3208

3209

3210
Exon # 66 Exon # 67
TTG GAA GAC AAG TAC AGA TAC CTT TTC AAG CAA GTG GCA AGT TCA ACA GGA TTT TGT GAC CAG CGC AGG CTG GGC CTC CTT CTG CAT GAT

Leu

Glu

Asp

Lys

Tyr

Arg

Tyr

Leu

Phe

Lys

Gln

Val

Ala

Ser

Ser

Thr

Gly

Phe

Cys

Asp

Gln

Arg

Arg

Leu

Gly

Leu

Leu

Leu

His

Asp

3211

3212

3213

3214

3215

3216

3217

3218

3219

3220

3221

3222

3223

3224

3225

3226

3227

3228

3229

3230

3231

3232

3233

3234

3235

3236

3237

3238

3239

3240
Exon # 67  
TCT ATC CAA ATT CCA AGA CAG TTG GGT GAA GTT GCA TCC TTT GGG GGC AGT AAC ATT GAG CCA AGT GTC CGG AGC TGC TTC CAA TTT GCT

Ser

Ile

Gln

Ile

Pro

Arg

Gln

Leu

Gly

Glu

Val

Ala

Ser

Phe

Gly

Gly

Ser

Asn

Ile

Glu

Pro

Ser

Val

Arg

Ser

Cys

Phe

Gln

Phe

Ala

3241

3242

3243

3244

3245

3246

3247

3248

3249

3250

3251

3252

3253

3254

3255

3256

3257

3258

3259

3260

3261

3262

3263

3264

3265

3266

3267

3268

3269

3270
Exon # 68
AAT AAT AAG CCA GAG ATC GAA GCG GCC CTC TTC CTA GAC TGG ATG AGA CTG GAA CCC CAG TCC ATG GTG TGG CTG CCC GTC CTG CAC AGA

Asn

Asn

Lys

Pro

Glu

Ile

Glu

Ala

Ala

Leu

Phe

Leu

Asp

Trp

Met

Arg

Leu

Glu

Pro

Gln

Ser

Met

Val

Trp

Leu

Pro

Val

Leu

His

Arg

3271

3272

3273

3274

3275

3276

3277

3278

3279

3280

3281

3282

3283

3284

3285

3286

3287

3288

3289

3290

3291

3292

3293

3294

3295

3296

3297

3298

3299

3300
Exon # 68 Exon # 69
GTG GCT GCT GCA GAA ACT GCC AAG CAT CAG GCC AAA TGT AAC ATC TGC AAA GAG TGT CCA ATC ATT GGA TTC AGG TAC AGG AGT CTA AAG

Val

Ala

Ala

Ala

Glu

Thr

Ala

Lys

His

Gln

Ala

Lys

Cys

Asn

Ile

Cys

Lys

Glu

Cys

Pro

Ile

Ile

Gly

Phe

Arg

Tyr

Arg

Ser

Leu

Lys

3301

3302

3303

3304

3305

3306

3307

3308

3309

3310

3311

3312

3313

3314

3315

3316

3317

3318

3319

3320

3321

3322

3323

3324

3325

3326

3327

3328

3329

3330
Exon # 69
CAC TTT AAT TAT GAC ATC TGC CAA AGC TGC TTT TTT TCT GGT CGA GTT GCA AAA GGC CAT AAA ATG CAC TAT CCC ATG GTG GAA TAT TGC

His

Phe

Asn

Tyr

Asp

Ile

Cys

Gln

Ser

Cys

Phe

Phe

Ser

Gly

Arg

Val

Ala

Lys

Gly

His

Lys

Met

His

Tyr

Pro

Met

Val

Glu

Tyr

Cys

3331

3332

3333

3334

3335

3336

3337

3338

3339

3340

3341

3342

3343

3344

3345

3346

3347

3348

3349

3350

3351

3352

3353

3354

3355

3356

3357

3358

3359

3360
Exon # 69 Exon # 70
ACT CCG ACT ACA TCA GGA GAA GAT GTT CGA GAC TTT GCC AAG GTA CTA AAA AAC AAA TTT CGA ACC AAA AGG TAT TTT GCG AAG CAT CCC

Thr

Pro

Thr

Thr

Ser

Gly

Glu

Asp

Val

Arg

Asp

Phe

Ala

Lys

Val

Leu

Lys

Asn

Lys

Phe

Arg

Thr

Lys

Arg

Tyr

Phe

Ala

Lys

His

Pro

3361

3362

3363

3364

3365

3366

3367

3368

3369

3370

3371

3372

3373

3374

3375

3376

3377

3378

3379

3380

3381

3382

3383

3384

3385

3386

3387

3388

3389

3390
Exon # 70 Exon # 71
CGA ATG GGC TAC CTG CCA GTG CAG ACT GTC TTA GAG GGG GAC AAC ATG GAA ACT CCC GTT ACT CTG ATC AAC TTC TGG CCA GTA GAT TCT

Arg

Met

Gly

Tyr

Leu

Pro

Val

Gln

Thr

Val

Leu

Glu

Gly

Asp

Asn

Met

Glu

Thr

Pro

Val

Thr

Leu

Ile

Asn

Phe

Trp

Pro

Val

Asp

Ser

3391

3392

3393

3394

3395

3396

3397

3398

3399

3400

3401

3402

3403

3404

3405

3406

3407

3408

3409

3410

3411

3412

3413

3414

3415

3416

3417

3418

3419

3420
  Exon # 72 Exon # 73
GCG CCT GCC TCG TCC CCT CAG CTT TCA CAC GAT GAT ACT CAT TCA CGC ATT GAA CAT TAT GCT AGC AGG CTA GCA GAA ATG GAA AAC AGC

Ala

Pro

Ala

Ser

Ser

Pro

Gln

Leu

Ser

His

Asp

Asp

Thr

His

Ser

Arg

Ile

Glu

His

Tyr

Ala

Ser

Arg

Leu

Ala

Glu

Met

Glu

Asn

Ser

3421

3422

3423

3424

3425

3426

3427

3428

3429

3430

3431

3432

3433

3434

3435

3436

3437

3438

3439

3440

3441

3442

3443

3444

3445

3446

3447

3448

3449

3450
Exon # 73 Exon # 74
AAT GGA TCT TAT CTA AAT GAT AGC ATC TCT CCT AAT GAG AGC ATA GAT GAT GAA CAT TTG TTA ATC CAG CAT TAC TGC CAA AGT TTG AAC

Asn

Gly

Ser

Tyr

Leu

Asn

Asp

Ser

Ile

Ser

Pro

Asn

Glu

Ser

Ile

Asp

Asp

Glu

His

Leu

Leu

Ile

Gln

His

Tyr

Cys

Gln

Ser

Leu

Asn

3451

3452

3453

3454

3455

3456

3457

3458

3459

3460

3461

3462

3463

3464

3465

3466

3467

3468

3469

3470

3471

3472

3473

3474

3475

3476

3477

3478

3479

3480
Exon # 74
CAG GAC TCC CCC CTG AGC CAG CCT CGT AGT CCT GCC CAG ATC TTG ATT TCC TTA GAG AGT GAG GAA AGA GGG GAG CTA GAG AGA ATC CTA

Gln

Asp

Ser

Pro

Leu

Ser

Gln

Pro

Arg

Ser

Pro

Ala

Gln

Ile

Leu

Ile

Ser

Leu

Glu

Ser

Glu

Glu

Arg

Gly

Glu

Leu

Glu

Arg

Ile

Leu

3481

3482

3483

3484

3485

3486

3487

3488

3489

3490

3491

3492

3493

3494

3495

3496

3497

3498

3499

3500

3501

3502

3503

3504

3505

3506

3507

3508

3509

3510
Exon # 74 Exon # 75
GCA GAT CTT GAG GAA GAA AAC AGG AAT CTG CAA GCA GAA TAT GAC CGT CTA AAG CAG CAG CAC GAA CAT AAA GGC CTG TCC CCA CTG CCG

Ala

Asp

Leu

Glu

Glu

Glu

Asn

Arg

Asn

Leu

Gln

Ala

Glu

Tyr

Asp

Arg

Leu

Lys

Gln

Gln

His

Glu

His

Lys

Gly

Leu

Ser

Pro

Leu

Pro

3511

3512

3513

3514

3515

3516

3517

3518

3519

3520

3521

3522

3523

3524

3525

3526

3527

3528

3529

3530

3531

3532

3533

3534

3535

3536

3537

3538

3539

3540
Exon # 75
TCC CCT CCT GAA ATG ATG CCC ACC TCT CCC CAG AGT CCC CGG GAT GCT GAG CTC ATT GCT GAG GCC AAG CTA CTG CGT CAA CAC AAA GGC

Ser

Pro

Pro

Glu

Met

Met

Pro

Thr

Ser

Pro

Gln

Ser

Pro

Arg

Asp

Ala

Glu

Leu

Ile

Ala

Glu

Ala

Lys

Leu

Leu

Arg

Gln

His

Lys

Gly

3541

3542

3543

3544

3545

3546

3547

3548

3549

3550

3551

3552

3553

3554

3555

3556

3557

3558

3559

3560

3561

3562

3563

3564

3565

3566

3567

3568

3569

3570
Exon # 75  
CGC CTG GAA GCC AGG ATG CAA ATC CTG GAA GAC CAC AAT AAA CAG CTG GAG TCA CAG TTA CAC AGG CTA AGG CAG CTG CTG GAG CAA CCC

Arg

Leu

Glu

Ala

Arg

Met

Gln

Ile

Leu

Glu

Asp

His

Asn

Lys

Gln

Leu

Glu

Ser

Gln

Leu

His

Arg

Leu

Arg

Gln

Leu

Leu

Glu

Gln

Pro

3571

3572

3573

3574

3575

3576

3577

3578

3579

3580

3581

3582

3583

3584

3585

3586

3587

3588

3589

3590

3591

3592

3593

3594

3595

3596

3597

3598

3599

3600
Exon # 76
CAG GCA GAG GCC AAA GTG AAT GGC ACA ACG GTG TCC TCT CCT TCT ACC TCT CTA CAG AGG TCC GAC AGC AGT CAG CCT ATG CTG CTC CGA

Gln

Ala

Glu

Ala

Lys

Val

Asn

Gly

Thr

Thr

Val

Ser

Ser

Pro

Ser

Thr

Ser

Leu

Gln

Arg

Ser

Asp

Ser

Ser

Gln

Pro

Met

Leu

Leu

Arg

3601

3602

3603

3604

3605

3606

3607

3608

3609

3610

3611

3612

3613

3614

3615

3616

3617

3618

3619

3620

3621

3622

3623

3624

3625

3626

3627

3628

3629

3630
Exon # 76 Exon # 77
GTG GTT GGC AGT CAA ACT TCG GAC TCC ATG GGT GAG GAA GAT CTT CTC AGT CCT CCC CAG GAC ACA AGC ACA GGG TTA GAG GAG GTG ATG

Val

Val

Gly

Ser

Gln

Thr

Ser

Asp

Ser

Met

Gly

Glu

Glu

Asp

Leu

Leu

Ser

Pro

Pro

Gln

Asp

Thr

Ser

Thr

Gly

Leu

Glu

Glu

Val

Met

3631

3632

3633

3634

3635

3636

3637

3638

3639

3640

3641

3642

3643

3644

3645

3646

3647

3648

3649

3650

3651

3652

3653

3654

3655

3656

3657

3658

3659

3660
Exon # 77 Exon # 78 Exon # 79
GAG CAA CTC AAC AAC TCC TTC CCT AGT TCA AGA GGA AGA AAT ACC CCT GGA AAG CCA ATG AGA GAG GAC ACA ATG TAG        

Glu

Gln

Leu

Asn

Asn

Ser

Phe

Pro

Ser

Ser

Arg

Gly

Arg

Asn

Thr

Pro

Gly

Lys

Pro

Met

Arg

Glu

Asp

Thr

Met

*

        

3661

3662

3663

3664

3665

3666

3667

3668

3669

3670

3671

3672

3673

3674

3675

3676

3677

3678

3679

3680

3681

3682

3683

3684

3685

3686